Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Klara Gado

Gabor Gigler

Csaba Szantay

Gyula Simig

Lujza E Petocz

Gabor Kovacs

Marton Fekete

Attila Mandi

Gabor Blasko

Eniko Szirt Nee Kiszelly

Frigyes Gorgenyi

Daniel Bozsing

Katalin Szemeredi

Andras Egyed

Ivan Beck

Lajos Novak

Istvan Simonyi

Margit Csorgo

Andras Dietz

Katalin Zukovics Nee Sumeg

Elemer Jakfalvi

Sandor Drabant

Maria Hegedus

Peter Kovacs

Julianna Takacs Nee Bitai

Gyorgy Pirok

This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The compounds according to the invention are characterized by the general formula (1) ##STR1## wherein R.sup.1 represents lower C.sub.1-4 alkyl, lower C.sub.1-4 alkoxy or lower C.sub.3-6 cycloalkyl,

Oxaindene derivatives and process for the preparation thereof

The compounds of the general Formula I ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different and each stands for hydrogen, hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy-C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy or phenyl-(C.sub.1-3 alkoxy), or R.sup.1 and R.sup.2 together form C.sub.1-2 alkylenedioxy; with the proviso that at least one of symbols R.sup.1 and R.sup.2 is other than hydrogen and with the further proviso that R.sup.1 and R.sup.2 can not represent 3,4-dimethoxy substitution) and their pharmaceutically acceptable acid addition salts exhibit useful analgesic, antipyretic, anti-inflammatory, anti-anginal and antioxidant effect.

Pharmaceutical compositions

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Budapest, Hungary

Klara Gado