Nycomed Imaging As

Amersham Health As

Ge Healthcare As

Ge Healthcare Limited

Nycomed Innovation Ab

Picker Nordstar Oy

Elementanalys Almen & Gronberg Ab

Claus Riemann & Co. Aps

Klaes Golman

Torsten Almen

Lars-Goran Wistrand

Sven Goran Andersson

Arne Berg

Ib Leunbach

Jo Klaveness

Stefan Petersson

Mikkel Jacob Thaning

Oskar Axelsson

Jan Henrik Ardenkjaer-Larsen

Georg Hansson

Hakan Wikstrom

Goran Pettersson

Frode Rise

Harald Dugstad

Michael Droege

Rolf Servin

Jan Wolber

Unni Nordby Wiggen

Haukur Johannesson

Tomas Klingstedt

Rune Fossheim

Peter Leander

Pangl Rongved

Peter Knox

Jan-Henrik Ardenkjaer-Larsen

Mikkel Jo Slashedrgensen

Neil Cook

Ib Luenbach

Oyvind Antonsen

Shi-bao Yu

Mark Howard

Oskar H E Axelsson

Hangkan Wikstrom

Gosta J Ehnholm

Pal Rongved

Graham John Cotton

Anne Kjersti Fahlvik

Mathilde H Lerche

Nigel Bosworth

Sven Mansson

Finn Radner

Ian R Young

Wolfgang H Gunther

Anna Rydbeck

Charlotte Olofsson

Haukur Johanneson

Herbert Baumann

Anne Jacobsen

Arne Aabye

Lars-Göran Wistrand

Lennart Hansson

O Slashedyvind Antonsen

Anna Rydeck

Thomas Gronberg

Soren Mattsson

Staffan Sjoberg

Rene Zandt

Albie Santos

Jan Henrik Ardenkj&aelig;r-Larson

Lars-G&ouml;ran Wistrand

Liv-Ingrid Degangrdstuen

Mike Looker

Ame Berg

Jan Jenrik Ardenkjaer-Larsen

Oksar Axelsson

Lars-G Oran Wistrand

Peter Michelsen

S B Yu

René Zandt

Mikkel Ge Healthcare As Thaning

Petersson Stefan

Jan-Henrik Ge Healthcare Ardenkjær-Larsen

The invention relates to a method of cardiac imaging using hyperpolarisedC-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.

Method of cardiac imaging

The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

Method for investigating the fate of a test compound or the stateof a biological system by means of NMR of hyperpolarised NMR active nuclei

The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.

NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target

An in vitro assay method which comprises the use of an assay reagent containing at least one NMR active nucleus, and hyperpolarising at least one NMR active nucleus of the assay reagent; and analysing the assay reagent and/or the assay by NMR spectroscopy and/or NMR imaging. The assay reagent may contain an artificially high concentration of an NMR active nucleus.

NMR spectroscopic in vitro assay using hyperpolarization

The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostatand then brought into solution while still inside the cryostat

Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses

The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cupin a strong magnetic field in a polarising meansin a cryostatand then melted inside the cryostatby melting means such as a laserconnected by an optical fibreto the interior of the cryostat.

Methods and devices for hyperpolarising and melting NMR samples in a cryostat

A method of magnetic resonance investigation of a sample by (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent; (ii) optionally, subjecting the hydrogenated MR imaging agent to a low magnetic field;(iii) administering the hydrogenated MR imaging agent to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of the selected non-zero nuclear spin nuclei from the sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from the detected signals.

Magnetic resonance imaging

The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.

Para-hydrogen labelled agents and their use in magnetic resonance imaging

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body. The method comprises the step of ex vivo polarization of a high T agent. The polarizing agent is optionally separated from the high T agent before the high T agent is administered to the sample.

Method of magnetic resonance investigation

The invention relates to a method of magnetic imaging (MR) of a living sample comprising the steps of hyperpolarizing a hyperpolarizable gas ex-vivo and transferring the nuclear polarization from the hyperpolarized gas to the nuclei of an MR imaging agent, that is not hyperpolarizable, that is exposed to a uniform magnetic field and that is introduced in contact to the hyperpolarizable gas, separating the hyperpolarizable gas from the MR imaging agent, administering the MR imaging agent to the living sample, exciting NMR transitions in the nuclei of the imaging agent and detecting an NMR signal thereof.

Method of magnetic resonance imaging

The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C,R,wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compound being water soluble at 20&deg; C. to a concentration of at least 350 mgl/ml and which in aqueous solution at 20&deg; C. at a concentration of 350 mgl/ml has a viscosity no greater than 13.8 mPas.

Iodinated x-ray contrast media

The use in diagnostic imaging, in particular X-ray, MRI, ultrasound and scintigraphy, of contrast agents comprising bismuth clusters and/or organic bismuth compounds, and contrast media containing such bismuth compounds. The bismuth compounds are also useful in therapy, in particular as antimicrobial agents and antiulcer agents. Novel bismuth compounds are also disclosed.

Bismuth compounds

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T,agent and wherein the polarising agent is optionally seperated from the high T,agent before the high T,agent is administered to the sample.

Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent

The invention provides a method of functional imaging of a human or non-human animal body, which method comprises administering into the gastrointestinal tract of a said body an effective amount of a composition comprising (a) a first contrast agent comprising a physiologically tolerable manganese compound or a salt thereof, together with (b) a second contrast agent, and generating a functional image of the gastrointestinal tract of said body. This imaging technique has surprisingly been found to provide clear delineation of those portions of the gut wall in which manganese uptake is occurring, thereby enabling not only the detection of tumors in the gut, but also the identification of regions of the gut which may be functioning abnormally.

Determination of non-functioning areas of the g.i. tract using MRI of

Non-cluster type bismuth compounds

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Rungsted Kyst, Denmark

Klaes Golman