Norsk Hydro, A.s.

Norskhydro Asa

Kjell Torgeir Stokke

Finn Myhren

Are Dalen

Bernt B&oslash;rretzen

Bernt Bo Slashedrretzen

New compounds of the general formula (I): Nu-O-Fa, wherein O represents an oxygen, Nu is a nucleoside or nucleoside analogue, and Fa is an acyl group of a mono-unsaturated C18 or 20 fatty acid. The invention also concerns anti viral pharmaceutical and veterinary compositions comprising a compound of formula (I) alone in a combination with a pharmaceutically acceptable carrier.

Fatty acid esters of nucleoside analogs

Therapeutic agents

This invention relates to new nucleoside derivatives of formula (I); wherein R,and R,are independently selected from hydrogen, elaidoyl, oleoyl, stearoyl, eicosenoyl (cis or trans) and eicosanoyl, with the provisos that R,and R,cannot both be hydrogen, oleoyl or stearoyl, R,cannot be hydrogen when R,is oleoyl or stearoyl, and R,cannot be hydrogen when R,is elaidoyl, oleoyl or stearoyl. Further, the invention relates to the use of the nucleoside derivatives of formula (I) wherein R,and R,are independently selected from hydrogen, and C,- and C,-saturated and mono-unsaturated acyl groups, with the provisos that R,and R,cannot both be hydrogen, in the manufacture of a pharmaceutical preparation for the treatment of tumours.

5'-O-acylated antiviral nucleosides

Growing community of inventors

Oslo, Norway

Kjell Torgeir Stokke