Astra Aktiebolag

Ab Astra

Kjell Goran Backstrom

Ann Charlotte Johansson

Peter Edman

Carl Magnus Dahlback

Magnus Jahnsson

Lars Asking

Henri Hansson

Richard Lindahl

Helena Linden

A therapeutic preparation for inhalation which comprises insulin and a substance which enhances the absorption of insulin in the lower respiratory tract, is provided in the form of a powder preparation suitable for inhalation.

Therapeutic preparation for inhalation

Inhaler

Powder formulations containing melezitose as a diluent

A pharmaceutical composition including a mixture of active compounds (A) a pharmaceutically active polypeptide, and (B) an enhancer compound which enhances the systemic absorption of the polypeptide in the lower respiratory tract of a patient, the mixture being in the form of a dry powder for inhalation in which at least 50% of the total mass of the active compounds consists of primary particles having a diameter less than or equal to about 10 microns, the primary particles optionally being formed into agglomerates.

Processes for preparing compositions for inhalation

Inhaler with deagglomerating device

A method of treating a patient in need of insulin treatment, including the steps of introducing into the lower respiratory tract of the patient an effective amount of a therapeutic preparation in the form of a dry powder containing (a) insulin and (b) an enhancer compound which enhances the absorption of insulin in the lungs of the patient.

Systemic administration of a therapeutic preparation

Growing community of inventors

Lund, Sweden

Kjell Goran Backstrom