Sumitomo Dainippon Pharma Co., Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

Kiyoto Sawamura

Yoshihiro Horiuchi

Hiroaki Fujiwara

Hiroyuki Nakahira

Yohei Ikuma

Hidenori Kimura

Izumi Sasaki

Kozo Yoshida

Nobuhisa Fukuda

Junya Ikeda

Hitoshi Suda

Satoshi Suetsugu

Yoshio Nakai

Mitsutaka Iwata

Akira Fusano

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); Rand Rmay be the same or different and each independently represents a Calkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; Xrepresents a hydroxyl group or an aminocarbonyl group; Zrepresents a single bond or the like; and Rrepresents an optionally substituted Calkyl group, an optionally substituted Caryl group or the like). 

8-azabicyclo[3.2.1]octane-8-carboxamide derivative

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is Carylene, etc.; R, Rand Reach independently is a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, etc.; Ris an optionally substituted Caryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted Caralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.) 

Cyclic amide derivative

The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein Ris halogen, etc.; Ris H, etc.; Gis &#x2014;N(R)&#x2014;, etc.; Gis &#x2014;CO&#x2014;, etc.; Gis &#x2014;C(R)(R)&#x2014;, etc.; Gis oxygen, etc.; Ris optionally substituted Calkyl, etc.; Rand Rare independently the same or different, H, etc.; Ris H, optionally substituted Calkyl, etc.; R, R, Rc and Rare independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

Bicyclic heterocyclic derivative

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Suita, Japan

Kiyoto Sawamura