Bristol-Myers Squibb Compnay

Bristol-Myers Company

Kiyoto Imae

Hajime Kamachi

Takaaki Okita

Shinji Masuyoshi

Takayuki Naito

Jun Okumura

Seiji Iimura

Shimpei Aburaki

Yukio Narita

The present invention relates to new cephalosporins of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or carboxy, with the proviso that both cannot be the same;

Antibiotic C-7 catechol-substituted cephalosporin compounds,

The present invention relates to new cephalosporins of the Formula ##STR1## wherein Y is N or CH;

Antibiotic C-3 di-hydroxyphenyl substituted cephalosporin compounds,

This invention relates to novel cephalosporin derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen, a straight, branched, or cyclic lower alkyl group having up to six carbon atoms or a radical of the formula ##STR2## in which R.sup.3 and R.sup.4 are each independently hydrogen, methyl or ethyl, or R.sup.3 and R.sup.4, taken together with the carbon atom to which they are attached, may be a cycloalkylidene ring containing from 3 to 5 carbon atoms;

Antibiotic C-3 catechol-substituted cephalosporin compounds,

Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is one of various alkyl, alkenyl, alkynyl, cycloalkyl, carboxyalkyl or carboxycycloalkyl moieties described herein, and R.sup.5 is hydrogen, amino, carboxy, formyl, carbamoyl, guanidino, amidino or one of various alkyl, alkoxy, alkylthio or substituted amino moieties described herein, and nontoxic pharmaceutically acceptable acid addition salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.

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Kawasaki, Japan

Kiyoto Imae