Otsuka Pharmaceutical Factory, Inc.

Otsuka Pharmaceutical Company, Limited

Kiyoto Goto

Kinji Hashimoto

Kenichi Kanai

Yoshiaki Tsuda

Yukihisa Ono

Yoshihiro Taniguchi

Yoshihisa Takaishi

Toshiko Kuwahara

Takuji Uesako

Masaaki Takai

Ken-ichi Kanai

Sachiko Manabe

Takahiro Asakuni

Phenanthrene derivatives

A p-aminophenol derivative having anti-inflammatory activity, represented by the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a C.sub.1-6 acyl group; Ar is a pyrazine, pyrazine N-oxide, thiazole, benzene, pyridine, pyridazine, pyrimidine or triazine ring; R.sup.3 is a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy-carbonyl-C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a halogen atom or a carboxy-C.sub.1-6 alkyl group; A is a C.sub.1-6 alkylene group; and B is a C.sub.1-6 alkyl group, or a salt thereof.

P-aminophenol derivatives, and processes for production of and uses for

This invention provides thiazole derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined above, and salts thereof. These compounds have particularly potent angiogenesis inhibiting activity.

Thiazole derivatives

Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group;

N-heterocyclo-substituted p-aminophenols

Disclosed are phenol derivatives of the formula ##STR1## wherein R.sup.1 is a substituted phenyl group, R.sup.2 and R.sup.3 are C.sub.1 -C.sub.6 alkyl group and of the formula ##STR2## wherein R.sup.8, R.sup.9 and R.sup.10 are C.sub.1 -C.sub.6 alkyl and the like and A is H, C.sub.1 -C.sub.6 alkylsulfonyl and the like substituents. These compounds and some related compounds have anti-inflammatory activity and lipoxygenase inhibitory activity.

Phenol derivatives, their preparation and the use thereof

N-pyrazinyl substituted P-aminophenols

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Naruto, Japan

Kiyoto Goto