Ube Industries, Inc.

Astra Zeneca U.k. Limited

Sankyo Company, Limited

Kiyotaka Yoshii

Katsumasa Harada

Shigeyoshi Nishino

Kenji Hirotsu

Kikuo Ataka

Akio Matsushita

Masayoshi Oue

Taku Nakamura

Koji Imaoka

Shuji Yamada

Yasuo Nakamura

Paul Michael Murray

Koichi Hirai

Atsushi Yamada

Yasunori Fukuda

Luis-Manuel Vaz

Debra Ainge

The present invention provides a hydrocracking catalyst obtainable by mixing a metal compound (A) including any one metal of Groups 3 to 11 of the Periodic Table, a compound (B) including at least one compound selected from the group consisting of a ruthenium oxide compound (B1) and a high-valence compound (B2) including any metal of Groups 8 to 11 of the Periodic Table, and a metal oxide (C) including a metal of Group 5, Group 6 or Group 7 of the Periodic Table, and conducting reduction treatment.

Hydrocracking catalyst, method for producing same, and method for producing hydroxy compound using said catalyst

A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2'-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2&#x2032;-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2&#x2032;-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2&#x2032;-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.

Process for preparing dibenzothiazepine compounds

A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f][1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2'-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2&#x2032;-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

Process for preparing dibenzothiazepine derivatives

The present invention relates to a process for preparing a &#x3b2;-oxonitrile compound or an alkali metal salt thereof which comprises reacting a carboxylic ester represented by the formula (1):RCOR&#x2003;&#x2003;(1) 

Process for producing &#x3b2;-oxonitrile compound or alkali metal salt thereof

A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f] [1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2'-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2&#x2032;-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

Process for producing dibenzothiazepine derivatives

Process for producing 2-substituted thiopyrimidine-4-carboxylate

A process for preparing an .alpha.-keto acid ester (oxo acid) of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, aliphatic alkyl group of 1-6 carbon atoms, phenyl group or benzyl group, and R.sup.2 is an aliphatic alkyl group of 1-6 carbon atoms, which comprises causing an .alpha.-hydroxycarboxylic acid ester of the formula: ##STR2## to react with molecular oxygen in a gaseous phase in the presence of copper phosphate, possibly, mounted on a solid carrier.

Preparation of .alpha.-keto acid ester

Disclosed are a process for producing a substituted phenoxyacetaldehyde oxime of the formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification), which comprises allowing a substituted phenoxyacetaldehyde dialkylacetal of the formula: ##STR2## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification) to react with hydroxylamine; a process for producing a substituted phenoxyethylamine of the formula: ##STR3## (wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification), which comprises reducing a substituted phenoxyacetaldehyde oxime of the formula (II) with hydrogen in the presence of a Raney-nickel catalyst; and a substituted phenoxyacetaldehyde oxime of the formula: ##STR4## (wherein R.sup.1, R.sup.2 and R.sup.6 are as defned in the specification).

Process for producing substituted phenoxyethylamines and intermediates

A process for producing a substituted phenoxyacetaldehyde oxime of the formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification), which comprises reacting a substituted phenoxyacetaldehyde dialkylacetal of the formula: ##STR2## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification) with a hydroxylamine at a pH of from 0.1 to 1.0.

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Ube, Japan

Kiyotaka Yoshii