Fujisawa Pharmaceutical Company, Ltd.

Kiyotaka Ito

Hisashi Takasugi

Takao Takaya

Masayuki Kato

Masayoshi Murata

Shigetaka Nishino

Hiroshi Miyake

Akira Yamada

Akito Tanaka

Masaki Tomishima

Glen W Spears

Fumie Takahashi

Amide compounds

The invention relates to a method of treating cardiac ischemic disease using a compound of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkenyl or N,N-di(lower)alkylaminomethyl,

Therapeutic agent for ischemic diseases

The present invention relates to novel pyrimidoindole derivatives and pharmaceutically acceptable salts thereof, in particular (+)-3,4-dihydro-5-methyl-2-[1-(5-methyl-1H-imidazol-4-yl)ethyl]pyrimido-[1 ,6-a]indol-1(2H)-one or its hydrochloride, useful for their 5-hydroxytryptamine antagonism.

Pyrimidoindole derivatives and processes for preparation thereof

A compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each hydrogen, lower alkyl, lower alkenyl, aryl or ar(lower)alkyl,

The invention relates to compounds for treatment of nausea and vomiting, of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkenyl or N,N-di(lower)alkylaminomethyl,

Pyridoindole derivatives and processes for preparation thereof

Compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or lower alkenyl, R.sup.2 is hydrogen, lower alkyl, or halogen, R.sup.3 is imidazolyl or pyridyl, each of which may have suitable substituents, and R.sup.4 is hydrogen, lower alkyl, lower alkenyl or hydroxy (lower) alkyl and R.sup.5 is hydrogen, hydroxy, or alkanoyloxy, or R.sup.4 and R.sup.5 are linked together to form an additional bond or novel pyridoindole derivatives which are useful as potent in selective antagonists of 5-HT receptors.

This invention relates to new 2(1H)-quinolinone compounds having the formula: ##STR1## wherein R.sup.1 is a imidazopyridyl, thiazolyl, indolyl, dihydroindolyl, imidazolyl, benzimidazolyl, quinolyl, isoquinolyl, quinazolinyl, dihydroisoquinolyl, tetrahydroimidazopyridyl or tetrahydroquinolyl, each of which may be substituted with substituents(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, ar(lower)alkoxy, cyano, nitro, amino, lower alkylamino, acylamino, hydroxy and oxo,

2(1H)-quinolinone compounds and pharmaceutical composition comprising

New pyrimidine derivatives of the formula: ##STR1## wherein Z is a group selected from ##STR2## in which R.sup.1 and R.sup.2 are each hydrogen, alkenyl, ar(lower)alkyl or lower alkyl optionally substituted with epoxy, hydroxy, amino and/or lower alkylamino and R.sup.5 is lower alkyl,

Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular

A compound of the formula: ##STR1## wherein R.sup.1 is pyridyl,

Pyridyl-imidazole compounds which have useful pharmaceutical activity

Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidone

The invention relates to pyrimidine compounds of the formula: ##STR1## wherein the substituents R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as herein defined, having activity as a cardiotonic, anti-hypertensive, cerebrovascular vasodilator and anti-platelet aggregation agent.

Pyrimidine compounds having activity as a cardiotonic anti-hypertensive

The invention relates to novel pyrimidinone compounds of anti-allergic and cardiotonic activity of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each lower alkyl, lower alkoxycarbonyl(lower)alkyl, carboxy(lower)alkyl or di(lower)alkylamino(lower)alkyl,

Growing community of inventors

Ikeda, Japan

Kiyotaka Ito