Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

University of Kentucky Research Foundation

Kiyoshi Tsuji

Takao Takaya

Hisashi Takasugi

Toshiyuki Chiba

Masaaki Matsuo

Katsuya Nakamura

Nobukiyo Konishi

Takashi Ogino

Tadashi Terasaka

Hiroyuki Okumura

Ikuo Ueda

Takashi Masugi

Takeshi Kato

Masayuki Kato

Glen W Spears

Takayoshi Kinoshita

Isao Nakanishi

Nobuo Seki

Osamu Nakaguchi

George A Digenis

Daizo Morino

Susumu Tsujimoto

Bushra J Agha

Nobuya Nishio

Akihiro Sato

Masako Kuno

Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein Ris optionally substituted aryl or optionally substituted heteroaryl, Ris lower alkyl; Ris hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective 

Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity

Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein R1 is aryl or heterocyclic group which is optionally substituted with substituent(s); Ris lower alkyl; Ris hydroxy or protected hydroxy; -A- is lower alkylene; and &#x2014;X&#x2014; is &#x2014;O&#x2014; or &#x2014;S&#x2014;; provided that when then Ris aryl which is substituted with substituent(s), or heterocyclic group which is optionally substituted with substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective. 

Imidazole derivatives as adenosine deaminase inhibitors

Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein Ris aryloxy, or aryl which is optionally substituted with suitable substituent(s); Ris lower alkyl; Ris hydroxy or protected hydroxy; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

Imidazole compounds and their use as adenosine deaminase inhibitors

Heterocyclic compound, composition and method for inhibiting adenosine deaminase

Imidazole compounds having adenosine deaminase inhibitory activity represented by formula (I) wherein R is hydrogen, hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s); R is hydrogen or lower alkyl; R is hydroxy or protected hydroxy; R is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, or carbamoyl optionally substituted with suitable substituent(s); and &mdash;A&mdash; is &mdash;Q&mdash; or &mdash;O&mdash;Q&mdash;, wherein Q is single bond or lower alkylene, provided that when R is lower alkyl, then R is hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

Imidazole compounds

Heterotricyclic derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, nitro, amino or protected amino,

Heterotricyclic derivatives, process for their preparation and

The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower) alkyl, cyano, lower alkylenedioxy, acyl, acyloxy, aryloxy and lower alkoxy optionally substituted with acyl or lower alkoxy,

Pyrazole derivatives, processes for preparation thereof and

This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsubstituted lower alkenyl, acyl, nitro, substituted or unsubstituted amino, sulfo, substituted or unsubstituted sulfamoyl, N-containing heterocyclicsulfonyl, hydoxy, substituted or unsubstituted heterocyclic group,

Thiophene derivatives

The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower)alkyl, cyano, lower alkylenedioxy, acyl, acyloxy, aryloxy and lower alkoxy optionally substituted with acyl or lower alkoxy, R.sup.2 is halogen, halo(lower)alkyl, cyano or acyl, and R.sup.3 is aryl substituted with nitro, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, provided that when R.sup.3 is aryl substituted with nitro, hydroxy or lower alkoxy, then R.sup.1 is aryl substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, and pharmaceutically acceptable salts thereof.

The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.

Pyrazole derivatives, and pharmaceutical composition comprising the same

This invention relates to new alkanesulfonanilide derivatives and pharmaceutically acceptable salts thereof which have inflammatory activities and analgesic activities, to pharmaceutical compositions containing the same and to a method for the treatment of inflammatory disease or pains in human beings and animals.

New alkanesulfonanilide derivatives, processes for preparation thereof

7-substituted 3-cephem or cepham compounds characterized by the grouping, in the 7-position thereof, of the formula:

Cephem and cepham compounds and processes for preparation thereof

An antithrombotic compound of the formula: ##STR1## wherein R.sup.1 is halogen,

Thiazolopyridine compounds, processes for the preparation thereof and

This invention relates to new alkane-sulfonanilide derivatives of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.8 are each hydrogen, cyano, halogen, lower alkyl, halo (lower) alkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl or lower alkoxy,

Growing community of inventors

Osaka, Japan

Kiyoshi Tsuji