Daiichi Sankyo Company, Limited

Kiyoshi Sugihara

Chiaki Ishii

Jun Hasegawa

Yusuke Ogitani

Yasuki Kamai

Shotaro Nagase

COMBINATION OF ANTIBODY-DRUG CONJUGATE AND TUBULIN INHIBITOR

A therapeutic agent for a metastatic brain tumor comprising, as an active component, an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents a connecting position to an antibody) is conjugated to the antibody via a thioether bond and/or a method of treatment for a metastatic brain tumor, comprising administering the antibody-drug conjugate to a subject in need of the treatment for a metastatic brain tumor.

Treatment of metastatic brain tumor by administration of an antibody-drug conjugate

The purpose of the present invention is to provide a substance having superior antibacterial activity against, and a pharmaceutical composition for treatment and/or prophylaxis of pseudomonal infections. A pharmaceutical composition is provided, containing an antibody which specifically binds to the LPS O11 antigen of, and which has superior antibacterial activity.

Anti-LPS O11 antibody

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Tokyo, Japan

Kiyoshi Sugihara