Sumika Fine Chemicals, Co.,ltd.

Sumitomo Chemical Company, Limited

Kiyoshi Sugi

Nobushige Itaya

Tadashi Katsura

Tetsuya Shintaku

Kozo Matsui

Yoshihiro Kawada

Masami Igi

Shigeya Yamazaki

Taro Ishibashi

Yoshihide Umemoto

Yayoi Tagami

Teiji Yamaoka

Masahide Tanaka

Hiroshi Shiratani

Mitsuhiro Iwasaki

Daisuke Sasayama

Hideto Miyamoto

Hiromi Suga

Disclosed is a method for production of an optically active biphenylalanine compound represented by the formula (2): (wherein, Ris a protective group of an amino group, and Rand Rare each independently a hydrogen atom, etc.)or a salt thereof and an optically active biphenylalanine ester compound represented by the formula (3): (wherein, Ris an alkyl group, etc.)wherein the method comprises hydrolyzing a biphenylalanine ester compound represented by the formula (1): with a protease produced by a microorganism belonging tosp. in the presence of at least one alkali selected from an alkali metal hydroxide and an alkaline earth metal hydroxide.

Method for production of optically active biphenylalanine compound or salt or ester thereof

The present invention provides a process for producing 4-(2-methylphenyl)benzotrifluoride, comprising reacting 4-chlorobenzotrifluoride with 2-methylphenylmagnesium chloride in the presence of cobalt-based catalyst and zinc salt.

Process for producing 4-(2-methylphenyl)benzotrifluoride

Process for preparing a piperidine derivative

Synthetic intermediate for epothilone derivative and production method thereof

Piperidine derivative and process for preparing the same

Production method of hydrazine derivative

A process for preparing tert-butyl 4&prime;-methyl-2-biphenylcarboxylate characterized in that 4&prime;-methyl-2-biphenylcarboxylic acid is reacted with isobutene in the presence of an acid catalyst. According to the present invention, tert-butyl 4&prime;-methyl-2-biphenylcarboxylate having high quality can be conveniently and industrially advantageously prepared in a high yield under mild reaction conditions such as ambient temperatures without complicated procedures or any hazardous solvents.

Process for producing tert-butyl 4&prime;-methyl-2-biphenylcarboxlate

Method for producing hydrazine derivative

A process for preparing a tert-alkyl carboxylic acid ester represented by the formula (III):

Process for preparing tert-alkyl ester from carboxylic acid

A series of compounds capable of deriving an intermediate for the production of compound (A) of the following formula,

2-phenylpyridine derivative and production method thereof

A series of compounds capable of deriving an intermediate for the production of a compound (A) of the following formula,

A series of compounds capable of deriving an intermediate for the production of a compound (A) of the following formula, ##STR1## which is an anti-HIV drug, and a production method thereof. To be specific, 4-(pyridin-2-yl)benzaldehyde hydrazone, a production method of this compound, and a production method from this compound to N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethyhidene]hydrazine. In addition, a salt of 2-(4-bromomethylphenyl)pyridine, 2-(4-dibromomethylphenyl)pyridine and a salt thereof, production methods of these compounds, and production methods to derive 4-(pyridin-2-yl)benzaldehyde which is a production intermediate for 4-(pyridin-2-yl)benzaldehyde hydrazone from these compounds.

A method of producing a 2-(p-alkylphenyl)pyridine compound economically, easily and industrially, which comprises adding manganese dioxide and trimethylchlorosilane, or adding manganese chloride to an organic ether solvent, and reacting p-alkylphenylmagnesium halide and 2-halopyridine in the obtained organic ether solvent.

Production method of 2-(p-alkylphenyl)pyridine compound

A process for preparing a 2-cyanobiphenyl compound represented by the formula (II): ##STR1## wherein R.sup.1 is an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or hydrogen atom, from a phenylmagnesium chloride compound represented by the formula (I): ##STR2## wherein R.sup.1 is as defined above. According to the process, a 2-cyanobiphenyl compound represented by the formula (II) can be economically, simply, industrially and advantageously prepared.

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Osaka, Japan

Kiyoshi Sugi