Shiseido Company, Limited

Victor Company of Japan, Limited

Kiyoshi Sato

Takako Shibata

Tomoko Saito

Kimihiro Ogino

Naoto Hanyu

Rikako Suzuki

Hirotada Fukunishi

Masaru Suetsugu

Kyoichi Shimizu

Ken Kusakari

Kiyotaka Hasegawa

Tokiya Yokoi

Naota Hanyu

Tadashi Takahaski

The present invention is directed to an extrace ofspp., as a skin whitening agent. Whitening agents according to the invention exhibit superior effects, for example, by lightening and whitening skin pigmentation, lightening and whitening aging spots, freckles, chloasma, or the like after sunburn. Thespp. extract of the invention has a superior free radical scavenging ability permitting the extract to control skin aging and skin diseases caused by active oxygen (free radicals), while having a high level of safety.

Whitening agent, anti-aging agent, and antioxidant agent

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein X, X, and Xare each CRor N; R, R, and Rare each H, Calkyl, Calkoxy, SH, OH, or NRR, wherein Rand Rare each H, Calkyl, or hydroxy-Calkyl, or NRRforms a saturated or unsaturated 5- or 6-membered hetero ring; and B is a substituted or unsubstituted pyrazole, imidazole, pyridine, or piperidine; with the proviso that at least one of R, R, R, and Ris a group other than Calkyl in the case where X&#x2550;X&#x2550;Y&#x2550;N and X&#x2550;CR.

Whitening agent and skin external preparation

The present invention provides a compound that has a high whitening effect and is excellent in safety and stability and provides an external preparation for skin comprising the same. The compound of the present invention is a 4-alkylresorcinol derivative represented by formula (1) or a salt thereof: 

4-alkylresorcinol derivative and external preparation for skin containing the same

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein, R, R, R, and Rare each independently Calkyl; and Rand Rare each independently a hydrogen atom or Calkyl.

Method for inhibiting melanin production and whitening skin with pyrimidlypyrazole compounds or pharmaceutically acceptable salts thereof

Method for inhibiting melanin production and whitening skin with pyrimidylpyrazole compounds or pharmaceutically acceptable salts thereof

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein R, R, and R' are each independently Calkyl; Y is S or O; and p is an integer of 0 to 3, wherein when p is 2 or 3, Rmay be the same or different.

Method for skin whitening

A compression and expansion system for a composite video signal comprises an extracting circuit for judging maximum and minimum points in a video signal of a composite video signal, to extract these maximum and minimum points, a digital value obtaining circuit for obtaining digital values of levels of the extracted points and digital values of positions of the extracted points in the video signal, to record and reproduce or transmit these digital values thus obtained, a circuit for performing interpolation to connect a digital value of the level and position of the extracted point which is reproduced or transmitted with a digital value of the level and position of a point which is succeedingly extracted, in a substantially linear manner, in order to expand the video signal, and a circuit for mixing a composite synchronizing signal which is separately produced with the analog video signal, to obtain the original composite video signal.

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Yokohama, Japan

Kiyoshi Sato