Kyowa Hakko Kogyo Co., Ltd.

Koito Manufacturing Company, Ltd.

Kiyoshi Sato

Tadashi Hirata

Takehiro Ogasa

Kenichi Mochida

Junichi Shimada

Ryo Okachi

Yukio Hashimoto

Akira Sato

Seigo Takasawa

Shigeru Kobayashi

Takanori Suzuki

Ikuo Matsukuma

Shigeo Yoshiie

Yoichi Ohashi

Chihiro Shiraki

Tadahi Hirata

A vehicular headlamp in which both a main beam unit and a sub-beam unit are supported by a single supporting member for aiming which is disposed within a lamp room defined by a headlamp body and an outer lens mounted on the lamp body for covering a front opening of the lamp body.

Vehicular headlamp

Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH.sub.2 ; n is an integer of 1 to 5; R.sub.1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R.sub.2 is a group represented by the formula: ##STR2## (where R.sub.4 is an unsubstituted or substituted phenyl or 2-aminothiazolyl) or a group represented by the formula: ##STR3## (where R.sub.5 is an unsubstituted or substituted lower alkyl); R.sub.3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R.sub.1 may be a quaternary ammonium group, where --CO.sub.2 R.sub.3 represents --CO.sub.2.sup.- ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.

3-heteroaralkylthio carbacephem compounds and antibacterial

Novel cephalosporin analogs are disclosed which have antibacterial activity. Methods for producing the compounds are also disclosed.

3-position halogenated cephalosporin analogs and pharmaceutical

.beta.-Lactam compounds represented by the general formula: ##STR1## (wherein X represents CH.sub.2, S or O; Y represents a hydroxyl group, a lower alkanoyloxy group or a lower alkoxycarbonyloxy group; W is a group represented by CH.sub.2, NH, ##STR2## A is a phenyl group, a naphthyl group, or a monocyclic or dicyclic heterocyclic group, respectively substituted by (Y).sub.n ; R.sub.4 and R.sub.5 each are a hydrogen atom, a lower alkyl group, or a cycloalkylidene group with a carbon atom combined therewith; l is 0 or an integer of 1, 2 or 3; m is 0 or 1; n is an integer of 1, 2, 3, 4 or 5; and R.sub.1, R.sub.2 and R.sub.3 are groups often used in the conventional .beta.-lactam compounds) have strong antimicrobial activities against a wide range of Gram positive and negative bacteria; particularly Gram negative bacteria including Pseudomonas aeruginosa, Pseudomonas sepatia and various Enterobacters.

.beta.-lactam compound and a pharmaceutical composition containing the

Optically active cephalosporin analogs of the formula ##STR1## wherein R.sub.2 represents a hydrogen or a group represented by the formula ##STR2## wherein R.sub.3 is a straight or branched lower alkyl group having 1 to 6 carbon atoms, a straight or branched lower alkoxy group having 1 to 6 carbon atoms or a phenyl group and R.sub.4 is a hydrogen or a straight or branched lower alkyl group having 1 to 6 carbon atoms; and A.sub.2 represents a straight or branched lower alkyl group having 1 to 6 carbon atoms or a straight or branched lower alkyl group having 1 to 6 carbon atoms which is substituted with one or two carboxyl groups, are useful as antibacterial agents.

Optically active cephalosporin analogs

Carbacephem compounds represented by the formula: ##STR1## [wherein R.sub.1 is a lower alkylsulfonyloxy, unsubstituted or substituted arylsulfonyloxy, azido, cyano, carbamoyloxy, unsubstituted or substituted heterocyclic thio ('heterocyclic' means a 5- or 6-membered heterocyclic group having 1 to 4 O, S or N atoms), unsubstituted or substituted lower alkylthio, or unsubstituted or substituted arylthio group; R.sub.2 and R.sub.3 are groups frequently used in the cephalosporin chemistry] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for curing various infections.

3-substituted carbacepem compounds having antibacterial effect

Disclosed are optically active cephalosporin analogs which are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.

Growing community of inventors

Shizuoka, Japan

Kiyoshi Sato