Fujisawa Pharmaceutical Company, Ltd.

Kiyoshi Okuda

Keiko Nakata

Kazumi Ohtomo

Kiyonori Okada

Toshinobu Uemura

Hisatomi Fukuoka

Minoru Nakano

Renji Aoi

Shinichi Morizane

A solid dispersion and a method of producing a solid dispersion of a sparingly water-soluble drug characterized by mixing the sparingly water-soluble drug and a water-soluble polymer at a temperature where neither the water-soluble drug nor water-soluble polymer is melted.

Method of producing a solid dispersion of the sparingly water-soluble

Combined bottle and cap

A drug delivery device includes a cylinder having a large diameter and a drug delivery member coaxially fitted to one end of the cylinder and in fluid communication therewith, the drug delivery member having a diameter substantially smaller than that of the cylinder. Drug delivery orifices are formed only at a side wall of the drug delivery member at an end thereof opposite the cylinder. A plunger fittable into an end of the cylinder opposite the drug delivery member has a disc portion and a central projection which fits into the drug delivery member. A cap covering the drug delivery member has an annular projection on the inside thereof for sealing the drug delivery member.

Drug delivery device

This invention relates to a fast release solid preparation, which comprises a solid dispersion composition containing dihydropyridien A compound uniformly dispersed in hydroxypropylmethyl cellulose as the dispersion medium, said dihydropyridine A compound being maintained in the amorphous state in said solid dispersion composition.

Fast release solid preparation of dihydropyridine a compound

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Ohtsu, Japan

Kiyoshi Okuda