Toray Industries, Inc.

Kiyoshi Okano

Tsuyoshi Matsumoto

Hideki Kawai

Yuji Sugawara

Yasumoto Adachi

Masanobu Naruto

Hirohiko Shimizu

Haruji Nakamura

Youhei Miyamoto

Yosuke Aoki

Satoko Takizawa

Katsuyuki Mori

The present invention relates to ketone derivatives represented by the following formula and medical agents containing the ketone derivatives or pharmacologically acceptable salts thereof as an active ingredient, and in particular, relates to a hematopoietic agent; it is shown that the present invention increases blood cells, such as platelets, white blood cells, and red blood cells, and is effective in preventing and treating cytopenia caused by cancer chemotherapy, radiation therapy, and the like.

Ketone derivatives and medical application thereof

The present invention relates to cyclic ketones represented by the following formula

Cyclic ketone derivatives and their medical applications

This invention relates to ketones represented by the following formula ##STR1## and to drugs in which such a ketone or pharmacologically acceptable salt thereof is an effective component. The ketones of the present invention encourage the production of platelets, red blood cells, white blood cells and the like, and can be used to prevent or treat cytopaenia brought about by cancer chemotherapy, radiotherapy, bone marrow transplantation and drug therapy, or by immunological abnormality or anaemia, and the like.

Ketone derivatives and their medical applications

The present invention offers the serine protease exhibiting a biological activity which a polypeptide having an amino acid sequence shown in FIG. 1 shows, the serine protease precursor where a cleavable peptide or signal peptide connects with the N-terminal of the said serine protease, and the gene encoding them. The serine protease being useful in medical treatment fields can be manufactured in large quantities by the present invention. Moreover, the present invention offers the DNA sequence coding a transcription controlling region contained in the chromosomal gene of the serine protease of a human myeloid cell. This sequence is the transcription controlling region being necessary for the gene expression being specific to a human leukocyte or erythrocyte.

Serine protease and serine protease gene

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Kanagawa, Japan

Kiyoshi Okano