Takeda Chemical Industries, Inc.

Taisei Corporation

Kiyoshi Nara

Kazuyoshi Katamoto

Kazuhiko Ohta

Mitsuko Asai

Kazuaki Kitano

Susumu Honda

Yasuhiro Sumino

Kazuhiko Kintaka

Akira Haze

Yasunori Matsuoka

Yoshio Nakao

Masahiko Tsuda

Takafumi Naito

Sadao Ohkido

Isao Yamamoto

Takefumi Shindoh

Hiroshi Yanome

Shigeru Suzuki

Kazunao Yokota

Shunichi Akiyama

This invention provides a hydraulic composition which contains a cementitious material in powder form, .beta.-1,3-glucan, and a superplasticizer. The composition makes it possible to prepare concrete with high resistance to segregation, high fluidity, and excellent filling ability. Because of this, vibration of the concrete is not necessary during casting; it can simply be poured.

Hydraulic composition, formed products therefrom and segregation

Monomeric human .gamma.-interferon is efficiently produced by subjecting crude human .gamma.-interferon to gel filtration in the presence of a reducing sulfur compound and a protein-denaturing agent.

Production of monomeric human .gamma.-interferon

The interseparating of desacetyl-cephalosporin C, desacetoxy-cephalosporin C and cephalosporin C can be accomplished by adsorbing these available cephalosporins on activated carbon and effecting a fractional elution thereof with water containing 0 to 20 percent (V/V) of an organic solvent or solvents.

Method for separating cephalosporins

The present invention relates to a method for concentrating a dilute aqueous solution of a .beta.-lactam antibiotic which is readily susceptible to heat, by subjecting a dilute aqueous solution of a .beta.-lactam antibiotic, said solution containing 2 to 20% (v/v) of a lower alcohol, to concentration by means of a permeable membrane made of poly(ether/amide) or polybenzimidazolone.

Method for concentrating .beta.-lactam antibiotic solution

Inosine and/or guanosine can be separated from fermentation broth containing microbial cells and high-molecular-weight substances by heat-treating said broth at 90.degree. to 110.degree. C., followed by subjecting to ultrafiltration. The present process is advantageously carried out in the industrial use of ultrafiltration.

Ultrafiltration of fermentation broth containing nucleosides to separate

A novel antibiotic P-2563 is produced by cultivating a microorganism of the genus Pseudomonas. The antibiotic is useful as a drug for the treatment of pustule, and also useful as a disinfectant.

Method for preparing antibiotic P-2563 using Pseudomonas fluorescens

Deacetoxycephalosporin C can be produced with advantage by fermentation of a microorganism which belongs to the genus Streptomyces, Cephalosporium, Emericellopsis, Paecilomyces, Anixiopsis, Arachnomyces or Spriroidium and is capable of producing deacetoxycephalosporin C. Deacetoxycephalosporin C is a useful antibiotic as such or can be used as a starting material for the production of other various cephalosporin antibiotics.

Production of deacetoxycephalosporin C

Growing community of inventors

Kyoto, Japan

Kiyoshi Nara