Futaba Denshi Kogyo K.k.

Futaba Denshi Kogyo Kabushiki Kaisha

Kyowa Hakko Kogyo Co., Ltd.

Kabushikikaisha Matsui Seisakusho

Kyowa Hakko Kirin Co., Limited

Other

Matsui Manufacturing Co., Ltd.

Horiba, Ltd.

Kyowa Hakko Kogyo Co., Ltd. Kabushiki Kaisha Matsui Seisakusho

Kiyoshi Morimoto

Toshinori Takagi

Hiroshi Watanabe

Yasushi Watanabe

Kazue Murata

Sanji Tokuno

Yukihiko Utamura

Eiji Hayakawa

Kunio Ito

Akikazu Iwamoto

Masuo Moriyama

Teiichi Miwa

Yoshika Sanada

Yuji Iwase

Motohiro Ohta

Shigeo Itoh

Hitoshi Toki

Yoshihisa Tsuruoka

Takeshi Tonegawa

Hiroshi Tada

Hirokazu Yoshimoto

Kimiaki Hayakawa

Yukio Ogawa

Mikio Yokoyama

Yoshitaka Koishi

Junji Nakagawa

Atsuroh Sonoda

Masahiko Shimizu

Satoru Hiruta

Hiroshi Kukimoto

Hiroyuki Morimoto

Takao Kishino

Yukihiko Shimizu

Takahiro Niiyama

Shinzo Ishii

Yoshitaka Satoh

Osamu Matsui

Matsui Osamu

Hideyuki Ikeda

Yasuhiro Ishikawa

Tomoaki Masada

Yorinobu Takino

Shigemitsu Miura

Satoshi Uzawa

Youichi Ikuta

Kakuei Matsubara

Junichi Miyabe

Eiichiro Hirota

Katsuya Watanabe

Murata Kazue

Tomohiko Goto

Akira Harada

An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 &#x3bc;m, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

Intrabuccally rapidly disintegrating tablet and a production method of the tablets

A tablet production apparatus comprising a gas generator G, a lubricant powder discharge meansfor discharging a lubricant powder into a gas generated from the gas generator G, depending on the supply of the gas from the gas generator G, and mixing the lubricant powder with the gas in dispersed state, a lubricant application meansfor spraying the lubricant powder discharged from the lubricant powder discharge meansand mixed with the gas generated from the gas generation means G in dispersed state, onto each material contacting surface of a die, an upper punch and a lower punch, and an oxygen concentration measuring meansfor measuring the oxygen concentration of the gas existing near the lubricant application means. The apparatus is designed such that the amount of the gas supplied into the lubricant application means is adjusted based on the oxygen concentration measured by the oxygen concentration measuring means

Tablet production method and tablet production apparatus

A pulsating vibration air generation apparatus capable of sharply and quickly controlling air flow in turning on and off operation, thereby generating a pulsating vibration air with sharp and hardly attenuated peak and valley, and capable of operation without occurrence of so much mechanical vibration. The pulsating vibration air generation apparatus is comprised of a main body having a tubular hollow space Rwith which two air communication ports are associated, and a rotary body situated for rotation in the tubular hollow space Rand which has a peripheral side surface Sso as to slide on the inner surface Sforming the tubular hollow space R

Pulsating vibration air generation apparatus

A powder material application apparatus capable of applying powder material uniformly onto lower surfaces of plural upper punches, upper surfaces of plural lower punches and inner circumferences of plural dies of a tabletting machine. Powder material is applied on a material contacting surface of the lower punch by spraying powder material mixed with air from a powder material spray port for lower punch of a powder material application part for lower punch. Powder material is applied on a material contacting surface of the upper punch wherein powder material is not applied enough according to gravity by spraying powder material mixed with air from a powder material spray port for upper punch while the upper punch moves from an initial end to a terminal end of the powder material spray port for upper punch. The powder material spray port for upper punch is provided along the rotary orbit of the upper punches and is elongated more than the powder material spray port for lower punch.

Coating device for powder material

According to the tablet production method of the present invention, tablet is produced by compressing molding material by means of punches and dies comprising the steps of using powdered or granular material including compound which is denaturalized or inactivated when tabletted at high pressure is used as the molding material, housing the punches and the dies in a spraying chamber, generating pulsating vibration air and spraying lubricant mixed in air in the spraying chamber, applying the lubricant on the surfaces of the punches and the dies while the lubricant sprayed in the spraying chamber is mixed with the pulsating vibration air, and tabletting the molding material by means of the punches applied with the lubricant on the surface thereof and the dies applied with the lubricant on the surface thereof.

Tablet manufacturing method and tablet

A quantitative discharge apparatus for powder material, comprising: a tubular body for storing powder material; and an elastic membrane having plural penetrating apertures, the membrane constituting a bottom of the tubular body. The elastic membrane is vibrated by applying a positive pulsating vibration air, and thereby discharging powder material stored in the tubular body from the penetrating apertures of the elastic membrane. The plural penetrating apertures of the elastic membrane are formed on the circumference of a circle, of which center is a specific point of the elastic membrane.

Constant volume delivery device and method of delivering powder material

A powdered material spraying device comprising a quantitative spraying device provided for a material discharge port of the powdered material storage hopper via a material feed valve, a cover being provided for the material feed port of the powdered material storage hopper. The spraying device includes a cylindrical body connected with the material discharge port of the powdered material storage hopper, an elastic membrane with a penetrating aperture provided so as to form a bottom of the cylindrical body at its lower opening end, and a dispersion chamber connected under the lower opening end of the cylindrical body via the elastic membrane. The dispersion chamber has a pulsating vibration air supply port for supplying a positive pulsating vibration air to the dispersion chamber and a discharge port. A bypass pipe is connected between the cylindrical body and the dispersion chamber and the powdered material is sprayed from a tip end of a conduit connected with the discharge port of the dispersion chamber.

Powder material spraying device

A tablet including active substance affected by lubricant, wherein the tablet is comprised of compressed mixture of active substance and adjuvant except for lubricant, and lubricant exists only on the surface of the tablet but is not included in the tablet. Such a tablet production method comprising the steps of producing mixture of active substance affected by lubricant and adjuvant, mixing lubricant powder with positive pulsating vibration air for dispersion, spraying the lubricant powder dispersed by the positive vibration air on a lower surface of an upper punch, an upper surface of a lower punch and an inner circumferential wall of a die, and tabletting the mixture by means of the upper and lower punches and the die.

Tablet and process for producing tablets

Pulsating vibration air generation apparatus comprising a cylindrical casing having an air supply port connected with an air source and a wave transmission port provided at the circumferential surface thereof, and a drum type rotary valve constructed rotatably in the casing, wherein the air supply port is located where a circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the wave transmission port is located apart from where the circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the drum type rotary valve is comprised of a rotary support shaft at a center axis, one end of the rotary valve is opened, another end of the rotary valve is closed, at least one ventilation window is provided at the circumferential surface of the rotary valve, the rotary valve is contained in the casing in such a manner that the open end of the rotary valve faces to the wave transmission port of the casing, and the at least one ventilation window provided at the circumferential surface of the rotary valve is designed to intermittently meet the air supply port according to rotation of the valve when a rotary drive apparatus is connected with the rotary support shaft and the rotary drive apparatus is driven.

Pulsating vibration air generation means

A production method and system for granulating powdered material wherein powdered material is fluidized by applying heated pulsating vibration air, and the fluidized powdered material is suspended up and down at a regular cycle by means of heated pulsating vibration air, the aggregated material is compressed by further vibration of pulsating vibration air, whereby the aggregated powdered material is efficiently made into granulated material with high density and rather small specific volume without causing projection on the surface and without being made porous. The production system is comprised of a granulation tank for storing powdered material to be granulated, the granulation tank having a supply port for introducing heated air at the bottom thereof, a discharge port for discharging the introduced heated air at the top thereof, and a fluidization bed provided above the supply port for receiving the powdered material. A spray apparatus for spraying a binder solution provided in the granulation tank for aggregating the powdered material stored in the granulation tank for growing the material is provided. An air source connected to the supply port of the granulation tank via a conduit pipe; heating apparatus interposed in the conduit pipe for heating the air generated from the air source; and a pulsating vibration air generation means interposed in the conduit pipe for converting the air generated from the air source to pulsating vibration air.

Production method and system for granulating powdered material

A method for producing tablet including active component, diluting agent, and lubricant by means of a tabletting machine provided with punches and dies, comprising steps of; preparing molding material including active component, diluting anent, and a part of lubricant; applying most of the remaining amount of the lubricant on surfaces of the punches and a surface of the die; and tabletting the molding material by means of the punches on which surfaces the lubricant is applied and the die on which surface the lubricant is applied

Process for the production of tablets and tablets

A dividable tablet is not chipped, can be divided easily and accurately, has excellent impact resistance and rarely causes twining in the film-coating step, wherein a dividing line is formed along a center line on the upper surface of the tablet, ridgelines are each located on an inner side of the peripheral portion of the tablet to surround the dividing line in two areas defined by the dividing line on the upper surface of the tablet, the lower surface of the tablet gradually rises from the peripheral portion of the tablet toward the center portion thereof, and areas around the ridgelines are each formed by a convex surface.

Dividable tablet and press-through pack

Growing community of inventors

Mobara, Japan

Kiyoshi Morimoto