Ajinomoto Co., Ltd.

Kiyoshi Matsuno

Takayuki Asahara

Yukiko Mori

Hiroaki Fukada

A purine-derived substance is produced by culturing a bacterium belonging to the genuswhich is able to produce purine-derived substance and has been modified so that enzymatic activity of fructose bisphosphatase is decreased, and collecting the purine-derived substance from the medium or cells.

Purine-derived substance-producing bacterium and a method for producing a purine-derived substance

By reacting inosinic acid (IMP) with a bacterium which has been modified so that IMP dehydrogenase activity and 5'-guanylic acid (GMP) synthetase activity are enhanced, GMP is produced.

Process for production of 5'-guanylic acid

A purine-derived substance is produced by culturing abacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial cells, and can be collected from the medium or the bacterial cells.

Purine-derived substance-producing bacterium and a method for producing purine-derived substance

A purine-derived substance is produced by culturing a bacterium belonging to the genuswhich has an ability to produce a purine-derived substance and has been modified so that enzymatic activity of transaldolase is decreased in a medium to cause accumulation of a purine-derived substance in the medium or cells, and collecting the purine-derived substance from the medium or cells.

Growing community of inventors

Kawasaki, Japan

Kiyoshi Matsuno