Kakenyaku Kako Co., Ltd.

Kiyoshi Ito

Jun Nakano

Yuji Suzuki

Kiyoshi Kuriyama

Masahiko Ikemoto

Kazuhiko Kimura

Teruo Nakanishi

Kiyonosin Itikawa

Katsuro Ishizuki

Coumarin derivatives of the general formula: ##STR1## wherein R is hydrogen atom, an alkyl group or an alkenyl group, R.sup.1 is hydrogen atom, an alkyl group, an alkenyl group or an alkoxy group, and the OR and R.sup.1 groups each are substituted at any of the 5, 6, 7 and 8 positions of the coumarin ring, and the salt thereof. The compounds are useful as antiallergic agent for preventing and treating allergic diseases.

3-(Tetrazol-5-yl), 4-methyl-8-alkoxy coumarins and anti-allergic

A pharmaceutical composition containing as the essential active ingredient a benzofuran derivative of the formula: ##STR1## wherein A is --COR', ##STR2## or ethyl group; B is hydrogen atom when A is --COR' ##STR3## or --COR' substituted at the 3 or 4 position of the benzofuran nucleus when A is ethyl; R is an alkyl group having 1 to 5 carbon atoms; R' is an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 3 carbon atoms or phenyl group; R' is an alkyl group having 1 to 4 carbon atoms, phenyl or phenylalkyl group wherein the alkyl moiety has 1 to 2 carbon atoms; and the substituted propoxy group is at the 3, 4, 5, 6 or 7 position of the benzofuran nucleus; or a pharmaceutically acceptable acid addition salt thereof in admixture with a pharmaceutically acceptable carrier. The pharmaceutical composition possesses a superior .beta.-adrenergic blocking activity and local anesthetic activity, and is useful for the prevention and treatment of heart diseases, hypertension and hyperthyroidism.

Pharmaceutical composition containing benzofuran derivative

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Otsu, Japan

Kiyoshi Ito