Kaken Pharmaceutical Company, Ltd.

Molecular Research Institute

Kiyoshi Inoguchi

Ping Huang

Nobuo Ishiyama

Tadashi Okuno

Satoru Ikegami

Hidenori Funamizu

Gilda Loew

Mitsuo Mimura

Keigo Hanada

Kiyoharu Ukai

Kazuyuki Furuya

Motonori Miyakawa

Naoya Nagata

Hirohide Ishige

Takeshi Kiyofuji

Shinji Tauchi

Linda J Maki, Legal Representative

Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals 

Amide derivatives

N-acylated lipophilic amino acid derivatives

Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical compositions containing the derivatives or the salts.

Tetrahydroquinoline derivatives

Disclosed are the novel compounds as growth hormone secretagogues represented by structural Formula (I), wherein Ris, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is &#x2014;CO&#x2014; or &#x2014;SO&#x2014;, Y is Formula (II), wherein n is an integer from 0&#x2013;4, Ris hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, Rand Rare independently selected from hydrogen, substituted or unsubstituted alkyl, or Rand Ror Rand Rare taken together to form substituted or unsubstituted alkylene, Ris hydrogen, or substituted or unsubstituted alkyl, Ris substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substituted or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.

Amide derivatives as growth hormone secretagogues

Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals

Growing community of inventors

Kyoto, Japan

Kiyoshi Inoguchi