Ube Industries, Inc.

Kiyoshi Fukui

Noboru Kakeya

Hiroshi Jibiki

Mitsushi Taguchi

Fumio Matsuo

Junichiro Kita

Kiyomi Okimoto

Fumio Kubo

Masayuki Watanabe

A process for producing recombinant human Cu, Zn-superoxide dismutase, which comprises treating a solution of copper-free or copper-deficient recombinant human Cu, Zn-superoxide dismutase with a copper salt in the presence of .beta.-mercaptoethanol.

Process for preparation of superoxide dismutase

There is disclosed a process for preparing a 1,2,4-triazole-3-carboxamide represented by the formula: ##STR1## wherein, R.sup.1 and R.sup.2 represent independently a hydrogen atom, an alkyl group, a cycloalkyl group or an aryl group, or both R.sup.1 and R.sup.2 represent an alkylene group linked with each other directly or through an oxygen atom or a nitrogen atom to form a ring together with the nitrogen atom to which they are attached, which comprises subjecting an oxamohydrazide represented by the formula: ##STR2## wherein R.sup.1 and R.sup.2 have the same meanings as defined above, to reaction with formamidine or a salt thereof.

Process for preparing 1,2,4-triazole-3-carboxamides

Novel orotic acid derivatives useful as agricultural chemicals or intermediates thereof are disclosed. The orotic acid derivatives are represented by the formula ##STR1## where Me is an alkali metal, R.sup.1 is an alkyl group of from 1 to 4 carbon atoms, an allyl group, a cyclohexyl group, a benzyl group, or a group ##STR2## (where R.sup.2 is an alkyl group of from 1 to 4 carbon atoms, an alkoxyl group of from 1 to 4 carbon atoms or a halogen atom and n is 0, 1, 2 or 3), m is an integer of 1 or 2, and X is a chlorine, bromine or iodine atom or a group --COR.sup.0 (where R.sup.0 is an alkyl group of from 1 to 4 carbon atoms or a phenyl group) when m is 1, and a group --COO.sup.- when m is 2.

Orotic acid derivatives

A process for preparing an amidinecarboxylic acid which comprises reacting, in water, an alkoxyiminoacetic acid ester represented by the formula ##STR1## (wherein R.sup.1 and R.sup.2 individually represent an alkyl group of 1 to 4 carbon atoms) with an amine represented by the formula

Process for preparing amidinecarboxylic acids

Hydantoin derivatives disclosed in the present application are represented by the formula ##STR1## wherein, R.sup.1 represents a hydrogen atom, an alkyl group of from 1 to 4 carbon atoms, an allyl group, a cyclohexyl group, a benzyl group or a group ##STR2## (where R.sup.2 is an alkyl group of from 1 to 4 carbon atoms, an alkoxy group of from 1 to 4 carbon atoms, a halogen atom or a nitro group, and n is 0, 1, 2 or 3), X.sup.1 is an alkoxycarbonyl group of from 2 to 5 carbon atoms, a benzoyl group, an aliphatic acyl group of from 2 to 5 carbon atoms or a cyano group, and Y is an alkoxycarbonyl group of from 2 to 5 carbon atoms or an aliphatic acyl group of from 2 to 5 carbon atoms. The hydantoin derivatives are useful as agricultural chemicals e.g. bactericides or intermediates thereof.

Hydantoin derivatives

Triphenylphosphine is produced in a high degree of yield by bringing pressurized hydrogen into contact with a triphenylphosphine dihalide dissolved in a solvent consisting of at least one member selected from monochlorobenzene and dichlorobenzenes.

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Ichihara, Japan

Kiyoshi Fukui