Tokyo Tanabe Company, Ltd.

Kiyokazu Murakami

Susumu Yokura

Naoto Matsuishi

Haruki Takeda

Kenichi Iizumi

Akira Hisamitsu

Hiroyuki Iizuka

Kouichi Matsunaga

Masao Yajima

Eiji Ohtubo

Nobuo Takoi

4-amino-5-oxy-2,6,6-trimethyl-2-cycloheptene compounds

A Saishin N derivative represented by the following general formula: ##STR1## wherein X represents a carbonyl group or a &gt;CH--ORx group, or X bonds to a carbon atom in Y or Z to represent a &gt;C(ORx)--O-- group; Y and Z may be the same or different and each represents a carbonyl group or a &gt;CH--ORy group, or each bonds to an oxygen atom in X to represent a &gt;CH-- group; the broken line represents an optional bond; and Rx and Ry may be the same or different and each represents a hydrogen atom or an alkyl, alkenyl, aralkenyl, aralkyl, heterocyclic-alkyl or acyl group, is provided which is therapeutically usable as an antiulcer agent.

Saishin N compounds, process for preparing same and antiulcer agents

There are provided 4,5-Dihydroxy-2,6,6-trimethyl-2-cyclohepten-1-one, a method for preparing the same and an antiulcer agent containing the same as an effective ingredient.

Antiulcer substance

Imidazo[4,5-b]pyridine compounds of the general formula [I] are provided: ##STR1## where R.sup.1 is straight-chain or branched C.sub.1-8 alkoxy which may be substituted with cycloalkyl, or C.sub.2-4 fluoroalkyloxy, R.sup.2 is H, methyl or methoxy, and R.sup.3 and R.sup.4 are each H or methyl and may be the same or different. All these compounds have good activity of inhibiting potassium ion-dependent adenosine triphosphatase and excellent storage stability, so that they are usable for the treatment of gastric and/or duodenal ulcers.

Imidazo[4,5-b]pyridine compounds and pharmaceutical compositions

Benzimidazole derivatives of the general formula [I] are provided: ##STR1## wherein R.sup.1 is hydrogen, methyl or methoxy, and R.sup.2 and R.sup.3 each is hydrogen or methyl, at least one of R.sup.1, R.sup.2 and R.sup.3 being a member other than hydrogen. The benzimidazole derivatives exhibit an excellent activity of inhibiting the potassium ion-dependent adenosine triphosphatase, as well as a good stability during storage. Therefore, the benzimidazole derivatives are usable for the treatment of gastric and/or duodenal ulcers.

Benzimidazole derivatives

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Yokohama, Japan

Kiyokazu Murakami