Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Kiyoaki Kobayashi

Fumihiro Ozaki

Yoshihiko Norimine

Kohei Sawada

Takashi Yoshinaga

Tatsuhiro Onogi

Hiroyuki Suzuki

Koki Kawano

Mutsuko Ono

Hiroe Minami

Toshihiko Kaneko

Yoshinori Takahashi

Motohiro Soejima

Masayuki Matsukura

Kazuki Miyazaki

Ichiro Yoshida

Hiroki Ishihara

Junichi Kamata

Eriko Doi

Noboru Yamamoto

Tasuku Ishida

Hiroshi Katoh

Nobuyuki Kurusu

Mutsuko Tabata

Daiju Hasegawa

Miyuki Ohkubo

Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q represents ethylene, etc., R, Rand Rrepresent hydrogen, etc., Xrepresents Calkylene, etc., Xrepresents Calkylene, etc., Arepresents a 5- to 6-membered heterocyclic group, etc., and Arepresents Caryl, etc.

Bicycloamine derivatives

Compounds represented by the following general formula: [wherein X, X, Xand Xeach independently represent a single bond, Calkylene, etc.; Arepresents optionally substituted phenyl, etc.; Arepresents an optionally substituted 5- to 7-membered heterocyclic group containing &#x2014;C(=Q)- (wherein Qrepresents oxygen, sulfur or &#x2550;N&#x2014;R(wherein Rrepresents hydrogen or Calkyl)) and nitrogen, etc.; and Zrepresents piperidin-diyl, etc.],salts thereof and hydrates of the foregoing.

Nitrogen containing heterocyclic compounds and medicines containing the same

The present invention provides compounds represented by the following formula:wherein X, X, Xand Xeach independently represents a single bond, Calkylene, etc.; Arepresents optionally substituted phenyl, etc.; Arepresents an optionally substituted 5- to 7-membered heterocyclic group containing &#x2014;C(&#x2550;Q)&#x2014;, Qwherein represents oxygen, sulfur or &#x2550;N&#x2014;R, wherein Rrepresents hydrogen or Calkyl etc.; and Zrepresents piperidin-diyl, ect, salts thereof and hydrates of the foregoing.

Piperidine compound and pharmaceutical composition thereof

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Moriya, Japan

Kiyoaki Kobayashi