University of Connecticut

Kishore Viswanathan

Dennis L Wright

Amy C Anderson

Eric William Scocchera

Janet Leigh Paulsen

Kathleen Mary Frey

Eric W Scocchera

Janet L Paulsen

Kathleen M Frey

The compositions and methods described herein disclose the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such asand methicillin-resistant, fungi such asandand protozoa such asand. These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.

Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase

Growing community of inventors

Mansfield Center, CT, United States of America

Kishore Viswanathan