Medtronic Vascular, Inc.

Monsanto Company

Medtronic, Inc.

Galera Labs, LLC

Nectero Medical, Inc.

Galera Therapeutics, LLC

Poly-med, Inc.

Vatrix Medical, Inc.

Udipi, Kishore

Kishore Udipi

Peiwen Cheng

Mingfei Chen

Ya Guo

Kaushik Aroonkumar Patel

Rangarajan Sundar

Lionel R Stebbins

William L Neumann

Joshua J Dwork

Samuel J Tremont

Adam Shipley

Susheel Deshmukh

Hubert K Yeung

Jeffrey W Allen

Daniela Salvemini

John P Shanahan

Amruta Reddy Poreddy

Shalaby Wahba Shalaby

Matthew F Ogle

Edward J Anderson

Allen R Padwa

Eugene Tedeschi

Wenda Carlyle

Patrice Tremble

Wenda C Carlyle

Todd Campbell

David Shumaker

Diane Judd

Su-Ping Lyu

Goman (Gomez) Peter M

Su Ping Lyu

Adam J Shipley

Dianne Judd

Patricia Tremble

Susheel R Deshmukh

A coated balloon device for stabilizing a section of a blood vessel in a living subject is disclosed. The coating layer of the coated balloon comprises a phenolic compound having a plurality of phenolic groups connected to form a hydrophobic core with peripheral phenolic hydroxyl groups. The coating layer of the coated balloon may contain a hydrophilic polymer to facilitate the release of the phenolic compound. The balloon in general is made of a compliant polymer for atraumatic contact with the blood vessel. In some embodiments, the coating of the coated balloon device further comprises a hydrophilic undercoat layer between the balloon and the coating layer. In some embodiments, the coated balloon device further comprises a sacrificial top coating that dissolves upon delivery into the section of the blood vessel and comprises a hydrophilic composition including sugar, sugar derivatives, or a combination thereof.

Coated balloons for blood vessel stabilization

Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.

Biocompatible controlled release coatings for medical devices and related methods

Implantable medical devices having a metallic surface coated with a bioabsorbable primer polymer layer under a bioabsorbable drug polymer layer. Thus, in addition to the degradation of the drug polymer layer, there is degradation of the primer layer. The underlying metallic framework may or may not degrade depending on whether bioabsorbable or biostable metals are chosen.

Implantable medical devices having bioabsorbable primer polymer coatings

Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds are also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.

Polyethylene glycolated superoxide dismutase mimetics

The present disclosure generally relates to biocompatible polymers for coating or fabricating implantable medical devices and to implantable medical devices having the present biocompatible polymers. The disclosed biocompatible polymers exhibit superior biocompatibility and therefore minimize unwanted immune reaction from a patient into whom a medical device is implanted.

Biocompatible polymers for coating or fabricating implantable medical devices

Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug.

Medical devices comprising polymeric drug delivery systems with drug solubility gradients

A percutaneous stented valve delivery device including an inner shaft, a sheath, and a delivery capsule. The sheath slidably receives the inner shaft. A capsule proximal zone is attached to the sheath. A capsule distal zone is configured to transition between normal and flared states. A diameter of the distal zone is greater in the flared state, and the capsule includes a shape memory component that naturally assumes the normal state. The device is operable to perform a reversible partial deployment procedure in which a portion of the prosthesis is exposed distal the capsule and allowed to radially expand. Subsequently, with distal advancement of the capsule, the distal zone transitions to the flared state and imparts a collapsing force onto the prosthesis, causing the prosthesis to radially collapse and become recaptured within the delivery capsule. The capsule can include a laser cut tube encapsulated by a polymer.

Stented transcatheter prosthetic heart valve delivery system and method

Biodegradable polymers useful for fabricating implantable medical devices and as coatings for medical devices are provided. The biodegradable polymers are biocompatible and can be tuned to provide optimum bioactive agent elution rates as well as degradation rates. Also provided are methods for making medical devices and medical device coatings using the biodegradable polymers.

Medical devices and coatings therefore comprising biodegradable polymers with enhanced functionality

The gradient coated stentof the present invention provides a coated stent having a continuous coatingdisposed on the stent elements. The continuous coatingincludes a first coating component and a second coating component. The concentration of the first coating component varies continuously over at least part of the thickness of the continuous coating. The concentration of the second coating component can also vary over at least part of the thickness of the continuous coating. In one embodiment, the concentration of the first coating component decreases in the direction from the stent element towards the outer edge of the continuous coatingand the concentration of the second coating component increases in the direction from the stent element towards the outer edge of the continuous coating

Gradient coated stent and method of fabrication

The present disclosure in a broad aspect provides for diazeniumdiolated phosphorylcholine polymers and associated methods for achieving nitric oxide release. The present polymers have superior biocompatibility and are useful for coating or fabricating medical devices such as a vascular stent.

Diazeniumdiolated phosphorylcholine polymers for nitric oxide release

The present invention provides a system for treating a vascular condition, including a catheter, a stent with a stent framework operably coupled to the catheter, and a drug-polymer coating on the stent framework including at least one plasticizer dispersed within the drug-polymer coating.

Plasticized stent coatings

Biocompatible polymers having polymer backbones with at least one secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-opening reactions are provided. More specifically, nitric oxide-releasing medical devices made using these polymers are disclosed.

Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation

Disclosed are hindered amine nitric oxide (NO) donating polymers for coating implantable medical devices. The polymers include sterically hindered secondary amines that do not react with monomer carbonyls or electrophilic alkenes, facilitating the synthesis of the NO donating polymers. The polymers are coated on implantable medical devices, providing anti-restenosis therapy by the release of NO at the implantation site.

Hindered amine nitric oxide donating polymers for coating medical devices

Growing community of inventors

Santa Rosa, CA, United States of America

Kishore Udipi