The Kendall Company

Bristol-Myers Squibb Compnay

Hercon Laboratories Corporation

Polytherapeutics, Inc.

E. R. Squibb Sons, Inc.

Ranir, LLC

Kishore R Shah

Agis F Kydonieus

Tak-lung Chang

Bret Berner

Samuel C Temin

Stefanie C Decker

Khosrow Jamshidi

Sheng-hung Kuo

Aruna Nathan

Jeffrey Joe Fisher

Raynold M Petrocelli

Wei-Chi Liao

Thomas J Franz

Leslie Klem

Dimitrios Apostolopoulos

Cuilian Lin

Donald J Therriault

Ladislav Bastar

Tak-Lung Chang

Sheng-Hung Kuo

An oral care composition including a hydrophilic, aliphatic, polyether-based thermoplastic polyurethane, a glycol polymer, and a poly(N-vinyl lactam). These components form a tacky film having a thickness of about 1 mils to about 50 mils. A whitening agent, such as a peroxide, can be absorbed into the tacky film, and adapted to desorb from the tacky film to whiten teeth to which the film is joined. A method is also provided in which the components are extruded through a twin screw extruder and output to a die to produce the film. The whitening agent can be deposited on the film and absorbed by the film to form a relatively stable oral care composition including the whitening agent.

Oral care layer and related method of manufacture

The invention provides a vessel for biological materials comprising a multilayer polymeric barrier material that has very low permeability to small molecules, such as water and oxygen, high flexibility and softness, and is resistant to tearing. The invention is particularly useful for forming vessels that receive biological fluids, such as ostomy bags and bags for storing blood, blood products, and IV solutions. The vessel comprises a flexible, multilayer, polymeric barrier material comprising (1) a first sandwich polymer layer, (2) at least one sandwiched, oriented liquid crystal polymer layer, and (3) a second sandwich polymer layer, the first and second sandwich layers disposed to sandwich the liquid crystal layer therebetween.

Ostomy bags and vessels for biological materials

A two part, polymerizable, skin sealant or shield which cures in situ to form a custom made, solid, shaped, skin friendly barrier which absorbs aqueous fluids without disintegrating.

Polymeric composition for sealing and shielding animal skin

Method for forming a polyurethane based adhesive composition in which a reaction mixture of at least one NCO-terminated prepolymer and a polyhydroxy compound is heated at a temperature and for a length of time sufficient to provide a gel content of from about 30 to 42% by weight and a molecular weight of extractables of at least about 45,000. Polyurethane based adhesives prepared by the method and medical devices employing the same are also disclosed.

Polyurethane pressure-sensitive adhesives

This invention pertains to mucoadhesive compositions for the delivery of pharmacologically active agents, and to polymeric formulations that allow for a prolonged, sustained release of the active agents. More specically the invention pertains to compositions for the delivery of drugs to mucosal tissue, said composition comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group, and at least one acidic hydrophilic monomer having an ethylenically unsaturated functional group.

Mucoadhesive compositions for administration of biologically active

Methods for producing poly�urethane-(meth)acrylate!-based adhesives in which an isocyanate-terminated prepolymer is reacted to convert the isocyanate terminal groups into groups capable of cross-linking with each other, excess isocyanate groups are quenched with an isocyanate group quenching compound and the resulting prepolymer is then irradiated or heated to form the polyurethane-based adhesives, and adhesives produced thereby. Alternatively, a hydroxyl-terminated prepolymer is reacted with a reagent having isocyanate and methacrylate groups to form a prepolymer which is then irradiated or heated.

A unidirectional buccal delivery system for the delivery of therapeutic agents over an extended period of time. The delivery system includes a matrix for releasing the drug into the oral cavity at a sustained rate and a means for securing the matrix to the palate or other adequate regions in the oral cavity.

Buccal delivery system for therapeutic agents

This invention pertains to the vaginal delivery of pharmacologically active agents and to polymeric formulations that allow for a prolonged release of the active agents in the vaginal environment. More specically the invention pertains to compositions for the delivery of drugs intravaginally comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group and at least one hydrophilic monomer having an ethylenically unsaturated functional group.

Hydrophilic polystyrene graft copolymer vehicle for intravaginal

In accordance with the present invention novel polyurethane PSAs containing water soluble polymer additives have enhanced water uptake. The water soluble polymer additives suitable for use herein have a solubility parameter in poorly hydrogen-binding solvents (e.g., hexane, cyclohexane and the like) in the range of from 8-10. The water soluble polymers must also be free from moieties which will react with isocyanates. Such PSAs retain their transparency and peel strength characteristics and can still be employed as relatively thin films (i.e., 2 to 100 mils) while exhibiting only minimal swelling when in contact with moist environments.

Water soluble polymer additives for polyurethane-based pressure

Pressure-sensitive adhesives which possess absorptivity and/or permeability properties to remove transepidermal water loss and/or other bodily fluids that come into contact with the adhesive, in combination with a fine balance of cohesion and adhesion properties, can be formulated by controlling the crosslinking of a polyurethane polymer having excess hydroxyl functionality, a glass transition temperature of less than about 0.degree. C., a moisture absorption of at least about 20% of its weight and/or a moisture vapor transmission rate of at least about 300 grams/meter.sup.2 /24 hours measured at 37.degree. C. and a 90% relative humidity gradient. Adhesives of these polymers possess a peel adhesion to human skin of between about 0.3 and 4 newtons/cm width of the polymer or adhesive.

A polymeric device for the controlled release of active agents contained in the device in which the polymer has a glass transition temperature greater than the normal storage or non use temperature of the device. When heated to or above the glass transition temperature of the polymer, the active agent is released. The release of active agent can be switched on or off by the adjustment of the temperature of the polymeric device above or below the glass transition temperature of the polymer.

Temperature activated controlled release

A composite material for wound dressings having a fibrous wound-contacting substrate, such as cotton gauze, impregnated with a thermoplastic hydrogel forming polymer and methods of making the same.

Thermoplastic hydrogel impregnated composite material

A device useful for administration of pharmacologically-active substances transdermally, orally, or by means of subdermal implant includes an impermeable backing layer, a plasticized polyvinyl chloride layer, and an adhesive layer, wherein the plasticized polyvinyl chloride layer includes from about 20 up to about 70% by weight of a polyvinyl chloride resin, from about 20 up to about 70% by weight of a plasticizer, and from about 0.5 up to about 35% by weight of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, nitroglycerin, and prostaglandin and optionally excipients.

Article useful for administration of pharmacologically-active substances

Described is a moisture-vapor-permeable and oxygen-permeable adhesive dressing for use in supplying a topical medicament to human skin in a controlled release manner, which dressing is unaffected by and impermeable to water in the liquid phase, which dressing when in use on human skin consists essentially of:

Moisture-vapor-permeable dressing

Described is a device for the controlled release and delivery to mammalian tissue of a pharmacologically active agent comprising:

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Bridgewater, NJ, United States of America

Kishore R Shah