Pfizer Corporation

Kishor A Desai

Gene M Bright

Mark Allen Sanner

Anton F Fliri

Thomas Francis Seeger

Bertrand Leo Chenard

John Eugene Macor

Harry R Howard, Jr

Anton F J Fliri

Kevin D Shenk

Teresa A Smolarek

Substituted pyrido[1,2-a]pyrazines of general formula I; wherein Ar and Arrepresent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO, CHOH, C&#x2550;O, or &#x2014;(CRR); and n is 0&#x2013;2, as well as precursors thereto, are ligands for dopamine receptor subtypes and serotonin (5HT) within the body and are therefore useful in the treatment of disorders of the dopamine and serotonin systems: 

2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors

5HT1 antagonists for antidepressant therapy

Substituted pyrido&lsqb;1,2-a&rsqb;pyrazines of general formula I; wherein Ar and Ar,represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO,, CHOH, C&boxH;O, or &mdash;(CR,R,); and n is 0-2, as well as precursors thereto, are ligands for dopamine receptor subtypes and serotonin (5HT) within the body and are therefore useful in the treatment of disorders of the dopamine and serotonin systems:

2,7-substituted octahydro-1H-pyrido&lsqb;1,2-A&rsqb;pyrazine derivatives as ligands for serotonin receptors

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.4, R.sup.23, R.sup.24, R.sup.25 and R.sup.26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent serotonin (5-HT.sub.1) agonists and antagonists.

Aryl and heteroaryl alkoxynaphthalene derivatives

2,7-substituted octahydro-1H-pyrido�1,2-a!pyrazine derivatives

Neuroleptic 2,7-disubtituted perhydro-1h-pyrido�1, 2-A!pyrazines

Neuroleptic 2-substituted perhydro-1-h-pyrido[1,2-a]pyrazines

Antipsychotic compounds having the formula ##STR1## wherein Z is H or Cl; Y is O or S; n is 1-4; separately, X is H or (C.sub.1 -C.sub.2)alkyl and L is R(CH.sub.2).sub.m CO, m is 0 or 1-3, R is (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, phenyl, naphthyl, furyl, benzofuranyl, thienyl, benzothienyl, pyrrolyl, indolyl, isoindolyl or one of said groups substituted on aromatic or heteroaromatic ring with fluoro, chloro, (C.sub.1 -C.sub.2)alkyl or (C.sub.1 -C.sub.2)alkoxy; or together L and X, in combination with the nitrogen to which they are attached, form certain cyclic imides, 4-substituted piperidines or a cyclic sulfonamide.

Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines

Anxiolytic agents which are racemic or optically active pyrido[1,2-a]pyrazine derivatives of the formula ##STR1## wherein x is N or CH and Y represents one of certain pyrazolo, triazolo, tetrazolo or cyclic imido radicals; and intermediates therefor.

Bis-aza-bicyclic anxiolytic agents

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Ledyard, CT, United States of America

Kishor A Desai