University Court of the University of St. Andrews

The Boeing Company

The University of Adelaide

Kishan Dholakia

Michael Mazilu

Praveen Cheriyan Ashok

Gajendra Pratap Singh

Michael Peter MacDonald

Zhengyi Yang

Tom Vettenburg

Barbara A Capron

Miguel Preciado

Mingzhou Chen

Antonia Erika Carruthers

William A McNeely

Jorg Baumgartl

Yoshihiko Arita

Frank Gunn-Moore

Anna Chiara De Luca

Klaus Metzger

Phillip Ronald Thomas Jess

Michael Macdonald

Thomas Fraser Krauss

Mario E Giardini

Christian Thomas Alcuin Brown

Robert Marchington

Gabriel Cooper Spalding

Lynn Paterson

Steven Leonard Neale

Michael Peter Macdonald

Jochen Arlt

Simon John Cran-McGreehin

Iain Cormack

Ashok Praveen

Khay Tan

Graham Milne

Daniel Rhodes

Igor Andreev

Tomas Cizmar

Mario Ettore Giardini

Nan Ma

David Stevenson

Philipp Ronald Jess

Simon John Cran-Mcgreehin

Christian Thomas Brown

Khai Tan

Francis James Gunn-Moore

A light sheet imaging system, such as a light sheet microscope, comprises an illumination arrangement for generating a light sheet for three-photon excitation of a fluorescent sample, and a fluorescence collection arrangement for collecting fluorescence generated in the sample as a result of three-photon excitation by the light sheet. The light sheet may be a non-diffractive, propagation-invariant light sheet. The light sheet may be formed from and/or comprise a Bessel beam. A method of light sheet imaging comprises using a light sheet for three-photon excitation of a fluorescent sample, and collecting fluorescence generated in the sample as a result of three-photon excitation of the sample by the light sheet. Such a method may be used for light sheet microscopy.

Three-photon light sheet imaging

A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer, and an optical system for coupling light from the optical source to a sample and for coupling light from the sample to the spectrometer and a further spectrometer. A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer and an optical system for coupling light from the optical source and a further optical source to a sample and for coupling light from the sample to the spectrometer. The optical system may be configured for coupling light from the optical source and the further optical source to the sample and for coupling light from the sample to the spectrometer and the further spectrometer. The Raman system may be portable and/or may be configured to be transported and/or carried and/or may be handheld.

Optical Raman system

A method and system are disclosed for use in imaging a sample. The method comprises illuminating a sample through a scattering medium, or illuminating a sub-surface region of the sample through a scattering surface region of the sample, with a plurality of spatial patterns of incident electromagnetic radiation, wherein each spatial pattern of incident electromagnetic radiation interacts with the sample, or the sub-surface region of the sample, to generate electromagnetic radiation in the sample or the sub-surface region of the sample. The method comprises measuring, for each spatial pattern of incident electromagnetic radiation, a corresponding value representative of a quantity of at least a portion of the emitted electromagnetic radiation and using the plurality of spatial patterns of incident electromagnetic radiation and the plurality of corresponding measured values to determine an image of the sample, or an image of the sub-surface region of the sample, without using a spatial distribution of the emitted electromagnetic radiation.

Imaging of a sample through a scattering medium

An optical coherence tomography system for imaging a sample is configured so as to illuminate a region of interest of the sample with incident light from an optical source. The optical coherence tomography system is further configured so as to interfere, on an optical detector, reference light from the optical source with offset returning light emerging from the sample along an offset collection path which is spatially offset from the region of interest of the sample, thereby creating interference on the optical detector.

Spatially offset optical coherence tomography

An optical system for generating an Airy beam light sheet comprising an optical arrangement for generating a Gaussian beam, and an optical element for converting the Gaussian beam into an Airy beam light sheet, wherein a single optical element is provided for converting the Gaussian beam into an Airy beam light sheet.

Airy beam light sheet and airy beam light sheet microscope

An optical system comprising trapping optics for forming an optical trap using counter propagating beams of light and light sheet imaging optics for light sheet imaging a particle, for example a cell, that is positioned in the optical trap, wherein the wavelength of the counter propagating beams of light and the wavelength of the light used for light sheet imaging are non-interfering.

Light sheet imaging microscopy using an optical trap

A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle whilst it is in the optical trap.

Method for obtaining a Raman spectrum of a sample or particle

An optical apparatus comprising a disposable non-magnetic optical fibre probe for coupling light into a sample and receiving light from the sample for performing Raman spectroscopy, and a non-magnetic optical extension releasably connected to the disposable non-magnetic optical probe for transmitting light into the disposable non-magnetic optical probe and receiving light from the disposable non-magnetic optical probe.

Optical apparatus for use with a medical imager

A light sheet optical system comprising means for forming a light sheet using a non-diffractive or quasi non-diffractive and/or propagation invariant beam that has an asymmetric intensity beam profile transverse to the direction of propagation, such as an Airy beam.

High resolution imaging of extended volumes

A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.

Method and device for analyzing alcoholic beverages

An optical system comprising a randomizer that has a plurality of randomly positioned scatterers for scattering and thereby randomizing light to generate a speckle pattern and a detector for detecting the speckle pattern to determine at least one property of the light and/or change in at least one property of the light.

Random wavelength meter

Raman spectroscopic detection device for measurement of a sample in a fluid channel

A method of minimizing cross-talk between optical modes propagating in a multi-mode optical fiber, comprises superimposing a plurality of optical wavefunctions; determining a relationship between superpositions of at least some of the optical wavefunctions and at least one measure of orthogonality of the optical modes at an output of the multi-mode optical fiber; and identifying a superposition of at least some of the optical wavefunctions that provides a desired or optimized value of the at least one measure of orthogonality using the determined relationship. The method further comprises generating, using light from a laser and at least one optical component, the identified superposition of at least some of the optical wavefunctions that provides the desired or optimized value of the at least one measure of orthogonality.

Minimization of cross-talk in a multi-mode fiber

Growing community of inventors

Fife, United Kingdom

Kishan Dholakia