Massachusetts Institute of Technology

Kiryl Piatkevich

Edward Stuart Boyden

Or A Shemesh

Changyang Linghu

Aimei Yang

Demian Park

Eunjung Jung

Won Min Park

The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to direct and localize sensor molecules in the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to determine activity in cells in which they are expressed.

Cell body targeted sensors

The invention, in some aspects, relates to dummy-fluorescent (DF) polypeptide molecules and their encoding nucleic acid molecules and use of such molecules in fusion proteins and their encoding nucleic acid molecules. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.

Dummy-fluorescent protein fusions and methods of use

Voltage reporter molecules and compositions, and methods for detecting voltage and voltage change in cells are provided. Also provided are methods for delivery, expression, and use of the voltage reporter molecules in cells, tissues, and subjects.

Genetically encoded red fluorescent voltage sensors enabling millivolt-resolution and high-speed neural voltage imaging

Growing community of inventors

Cambridge, MA, United States of America

Kiryl Piatkevich