Venenum Biodesign, LLC

Kiruthika Selvarangan Elamparuthi

Jeffrey John Letourneau

Chia-Yu Huang

Venugopalareddy Bommireddy Venkata

The present invention provides compounds of Formula I: wherein X, R, R, Rand Rare as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the TREX1 protein and thus can be used as medicaments for treating or preventing disorders affected by the inhibition of TREX1.

Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors

The present invention provides compounds of Formula I wherein X, R, R, Rand Rare as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the TREX1 protein and thus can be used as medicaments for treating or preventing disorders affected by the inhibition of TREX1.

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Princeton Junction, NJ, United States of America

Kiruthika Selvarangan Elamparuthi