Dupont Nutrition Biosciences Aps

Danisco A/s

Kirsti Tiihonen

Nina Rautonen

Heli Putaala

Rodolphe Barrangou

Arthur Ouwehand

Sampo Lahtinen

Rémy Burcelin

Didier Carcano

Pierre Desreumaux

Marta Korczynska

Wouter Herman Noordman

Heli Anglenius

Juha Apajalahti

Marta Zdzislawa Korczynska

The present invention relates to a probiotic bacteria, and/or soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria for use in the treatment of a disorder associated with Tight Junction function, characterised in that the probiotic bacteria, soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria is formulated for topical administration.

Probiotic bacteria for the topical treatment of skin disorders

The invention relates to use of a bacterium selected from a lactic acid bacterium, aor a mixture of any thereof for treating metabolic endotoxemia, inhibiting bacterial translocation and regulating lipid absorption in a mammal.

Lactic acid bacteria andfor treating endotoxemia

Lactic acid bacteria and bifidobacteria for treating endotoxemia

Use of at least one strain of a microorganism and/or a metabolite thereof in the manufacture of a support for administration to a subject for modulating satiety signalling, wherein the support is a pharmaceutically acceptable support or a food product. Suitably, the at least one strain of a microorganism and/or a metabolite thereof may be administered to the subject for the treatment and/or prevention of excess weight and/or a disease caused by excess weight. Likewise, the at least one strain of a microorganism and/or a metabolite thereof is administered to the subject for the treatment and/or prevention of obesity and/or a caused by obesity. Preferably, the microorganism is a probiotic microorganism. Suitably the microorganism may be a lactic acid bacterium. Li one embodiment the microorganism is a strain ofspp. and/orspp., for example a strain ofand/or

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Helsinki, Finland

Kirsti Tiihonen