Agilent Technologies, Inc.

Dako Denmark A/s

Kirsten Damgaard Hoff

Jesper Lohse

Kristian Jensen

Lars Christian Jacobsen

Jakob O Gjørret

Henrik Winther

Kurt Pii

Rikke Malene Krusenst Jerna-Hafstrom

Sussie Steen Jensen

Rikke Malene Krusenstjerna-Hafstrom

Rikke Malene JØRGENSEN

Jakob O GJØRRET

The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

Method for evaluation of target in histological sample

The present invention relates to anti-human PAX 5 antibodies capable of binding to one or more epitopes located within the C-terminal regulatory domain of PAX 5. In particular the invention relates to an antibody, antigen binding fragment or recombinant protein thereof, which is capable of specific binding to an epitope located within the C-terminal fragment of human PAX 5 protein, wherein said epitope comprises from 3 to 17 amino acid residues of amino acid sequence GSPYYYSAAARGAAPPA (SEQ ID NO:2). The invention also relates to immunogenic peptide sequences for the production of the antibodies, diagnostic and therapeutic applications comprising using the antibodies and formulations comprising thereof.

PAX 5 monoclonal antibody

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Måløv, Denmark

Kirsten Damgaard Hoff