University of South Florida

The United States Government As Represented by the Department of Veterans Affairs

Kirpal Singh Bisht

Alberto Van Olphen

Pasha M Khan

Niketa A Patel

Rekha S Patel

Dean F Martin

Cynthia Bucher

Jahanshah Amin

Ruizhi Wu

Meghanath Gali

Described herein are compositions for non-aqueous lithium ion extraction and methods of non-aqueous lithium ion extraction. In some embodiments, Octolig&#xae; or a methyl derivative thereof can be used to extract lithium and/or other ions from a non-aqueous substrate.

Lithium ion extraction methods

Modified stilbenoids and formulations thereof are provided. The modified stilbenoids can include one or more amino or amino-alkyl substituents. The formulation can be for the treatment or prevention of obesity and the modified stilbenoid present in an effective amount to alleviate or prevent the onset of one or more symptoms of obesity. Methods of making the modified stilbenoids and formulations thereof are provided. Methods are provided for treating a subject with a modified stilbenoid in an effective amount to alleviate or prevent one or more symptoms associated with diabetes, cardiovascular disease, high blood pressure, deep vein thrombosis, osteoarthritis, obstructive sleep apnea, cancer, and non-alcoholic fatty liver disease. The administration of the modified stilbenoids can result in decreased levels of PKC&#x3b4;II, PKC&#x3b4;VIII, substantially unaltered expression of PKC&#x3b4;I; a decreased number of adipocytes; increased weight and/or fat loss; or a combination thereof.

Compositions and methods for adipocyte modulation

Embodiments of the present disclosure provide compositions including ketamine analogs, salts, and disalts, pharmaceutical compositions including ketamine analogs, salts, or disalts, methods of treatment of a condition or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Compositions, methods of use, and methods of treatment

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (&#x3e;99% ee) was influenced by desymmetrization catalyzed bylipase and the stereo selective nature of the palladium catalyzed transformations.

Antiviral activity of cyclopentene nitro-ester and derivatives

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (&#x3e;99% ee) was influenced by desymmetrization catalyzed bylipase and the stereoselective nature of the palladium catalyzed transformations.

Growing community of inventors

Tampa, FL, United States of America

Kirpal Singh Bisht