Kureha Kagaku Kogyo Kabushiki Kaisha

Kureha Chemical Industry Company, Limited

Toyo Boseki Kabushiki Kaisha

Kiro Asano

Humio Tamura

Tsuyoshi Saito

Hiromitsu Tanaka

Satoru Enomoto

Fumio Tamura

Satoshi Mitsuhashi

Tadahiro Matsudaira

Yoshio Kawai

Hisayuki Wada

Susumu Ikeda

Masayoshi Hatanaka

Yoichi Suzuki

Masaaki Takahashi

Hiroto Fujimaki

Koji Seguchi

Takuji Hosoi

Tadashi Araki

Kenji Bannai

Akira Iizuka

Tsutomu Konno

Fumio Kodama

Jun Yamada

Kiyoshi Yamaki

Takao Awao

Reiho Takabe

Yushi Nezu

Satoru Enomotol

Toichi Suzuki

Hisao Imaizumi

The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different.

Method for suppressing an immunoresponse with an estradiol

An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.

Estradiol derivative-chlorambucil conjugate, process for preparing the

Estradiol derivative-chlorambucil conjugate process for preparing the

Dietary fiber, obtained from extracting wheat bran with water, having an average molecular weight of 5.times.10.sup.2 to 1.times.10.sup.5, from 95.3 to 99.0% by weight of a sugar, primarily glucose, and 0.1 to 3.0% by weight protein components. The fiber, when eaten, promotes the digestion and absorption of nutrients, waste excretion and proliferation of Lactobacillus bifidus in the large intestine.

Dietary fiber extracted from wheat bran pharmaceutical and dietary

Disclosed herein are (1) a fluorescent substance represented by the formula (I), (2) a process for producing the fluorescent substance, and (3) a cell-discriminating agent containing the fluorescent substance as an active ingredient. ##STR1## (wherein n is an integer of 0, 1, 2 or 3 and R represents a residual radical of a fluorescent material.)

Chlorambucil derivatives and cell-discriminating agent containing the

Disclosed herein is an injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-bis(2-chloroethyl)amino)phenyl }butanoyloxy]acetate, which has been known as an orally administrable anti-tumor substance, as an active ingredient and an ester of iodinated poppy oil fatty acid as a solvent.

Injection containing

Disclosed herein is an immunoregulator comprising a derivative of estradiol represented by the formula (I), which immunoregulator has a small influence to the non-specific immunoreactions in general and gives a specific influence to the immunoreactions against an isoantibody. ##STR1##

Immunoregulator comprising a derivative of estradiol

A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of ##STR2##

Steroid hormone-antitumor derivatives

The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formula

Chlorambucil derivatives

Methylated prostaglandine derivatives are steroids derivatives having at 17 position, methylated prostaglandine group such as

Methylated prostaglandin derivatives

Conjugates of amino sugar-steroid hormone are prepared by binding an amino sugar to steroid hormone at 3- or 17-position by a direct reaction or by binding with a binding agent, and the conjugate is useful in an enzyme immunoassay method.

Conjugate of amino sugar-steroid hormone

Solid carbon material having extremely high flexural strength can be produced by introducing a sufficient amount of functional group to satisfy the undernoted general equation into a pitch having a H/C atomic ratio of 0.8 at most, thereby obtaining precursory carbon material; shaping said precursory carbon material into a desired article without using any binding material; and carbonizing or further graphitizing said article; wherein the general equation is ##EQU1## where, H/C is the hydrogen-to-carbon atomic ratio of the pitch, R is a numeral ranging from 0.2 to 0.3, and f is the percent by weight of at least one of oxygen, sulfur and halogen contained in the total functional groups introduced into the precursory carbon material on the basis of the weight thereof.

Method for producing solid carbon material having high flexural strength

Process for the preparation of Chlorambucil derivatives

A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of --O--, --COO--, --CONH--, --NH-- or ##STR2##

A novel product comprising nitrogen-containing polysaccharides is produced by bringing a culture product of fungi Basidomycetes into reaction with an aqueous ammoniacal solution at a temperature of 100.degree. to 250.degree. C. The product is remarkably effective in controlling various plant viruses.

Growing community of inventors

Kukizaki, Japan

Kiro Asano