Purdue Research Foundation

Methodist Hospital of Indiana, Inc.

Kirk Solon Foster

Leslie A Geddes

James Thomas Jones

Rebecca A Roeder

Derek Tully

Scott Kepner

Jessica E Huber

Stephen Francis Badylak

Michael Ralph Ladisch

Robert J Demeter

Craig Jonathan Goergen

William E Schoenlein

George P Graber

George R Wodicka

Thomas Richard Kreke

Eduardo De Aquino Ximenes

David Reuter

Claude B Harrington

Xingya (Linda) Liu

Seockmo Ku

Alisha Tungare

Jaycey Hardenstein

Amanda Deering

Xingya (linda) Liu

Eduardo De Aquino Ximines

Methods for rapidly concentrating a food sample for efficient detection of bacteria are disclosed. A microfiltration approach followed by centrifugation was used to concentrate the cells with an enzyme (e.g., a protease) added at the beginning of the process to facilitate more efficient micro-filtering. The enzyme was found to have no significant effect on cell viability.

Rapid concentration, recovery and detection of pathogens in food samples

An integrated triad system to measure a patient's blood pressure at different body positions, to instruct the patient when to move from one position to the next to alleviate vascular hypertension based on an algorithm stored in the system calculating blood pressure changes and predictive risk, and to transmit the result to a remote medical location. Using the integrated triad system to perform the test over a period can increase test sensitivity by accommodating the variable onset of the disease.

Diagnostic and therapeutic device for compromised vascular hemodynamics analysis

A voice enhancement device including an earpiece configured to be positioned in an ear canal of a user. A microcontroller is operatively coupled to the earpiece. The microcontroller is configured to selectively provide at least multitalker babble. An accelerometer is located within the earpiece and operatively coupled to the microcontroller. The accelerometer is configured to detect speech by the user and communicate with the microcontroller to provide the multitalker babble to the earpiece during the detected speech by the user. A method of making the voice enhancement device, and a method for increasing vocal loudness in a patient using the voice enhancement device are also disclosed.

Devices that train voice patterns and methods thereof

One example embodiment of the present disclosure includes method and system to improve communication comprising an assembly fixedly positioned during use in close proximity to a user's ear. The assembly includes an accelerometer to detect the initiation and duration of the user's speech and an output presentation system. The output presentation system comprises a non-occlusive ear fitting that presents unintelligible noise that is unrelated to the sound-frequency or intonation of the user's current speech. The unintelligible noise is presented to the patient at a level less than 85 dB. The system further comprises a control arrangement to maintain presentation of the noise substantially throughout the detected duration of the user's speech, but substantially not at other times.

Method and system for training voice patterns

An auditory pulse monitor for noninvasively detecting the amplitude of arterial pulses on a beat-by-beat basis. A light-weight optical sensor including a light source and photodetector is adapted for application to the skin surface of a subject over a tissue bed containing an arterial supply. The photodetector generates an output signal proportional to the amplitude of an arterial pulse, and an electronic circuit connected to the photodetector generates a signal having a frequency proportional to the photodetector output signal level. A speaker or other audio indicator connected to the electronic circuit generates an audible tone indicating the amplitude of the arterial pulse. Another aspect of the invention is an improvement in automated or automatic external defibrillators (AEDs). An AED is disclosed which optically detects arterial pulses after delivering a defibrillation shock and signals the need for CPR if it detects inadequate cardiac pumping following successful defibrillation.

Apparatus and method for noninvasively detecting the quality of cardiac pumping

An optical noninvasive vital sign monitor comprising a reflectance-type optical sensor within a pressurizable capsule retained by a headband, the capsule having an optically transparent or translucent inner wall adapted for placement against a subject's forehead. The optical sensor is mounted on the inside surface of the pressurizable capsule's inner wall, which contacts the subject's forehead during use, and includes a light source and a photodetector aimed toward the inside surface of the inner capsule wall. One embodiment of the vital sign monitor includes optical oscillometric circuit means responsive to an output signal from the optical sensor for determining systolic pressure, mean pressure and diastolic pressure during a transition in capsule pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure.

Optical noninvasive vital sign monitor

A member-illuminating cuff for measurement of systolic, mean and diastolic pressure, oxygen saturation, pulse and respiratory rate in small body members, comprising a hinged cuff housing, one or more light sources mounted on a first section of the housing, a photodetector mounted on a second section of the housing, and a disposable, inflatable cuff adapted to fit within the cuff housing and around a body member placed therein.

Body-member-illuminating pressure cuff for use in optical noninvasive measurement of blood parameters

A device is provided for facilitating oral administration of unit dosages of liquid formulations, particularly to pediatric and geriatric patients. Sealed cartridges containing unit doses of liquid nutrients or medications can be locked into the device and at the same time, breached so that the contained-liquid formulation can flow from the cartridge into a hollow nipple for facile oral consumption. The liquid formulation-contained sealed cartridge includes a container having a side wall collapsible responsive to withdrawal of liquid from the hollow nipple.

Device for oral administration of liquids

Growing community of inventors

West Lafayette, IN, United States of America

Kirk Solon Foster