The United States of America As Represented by the Secretary of

The United States of America As Represented by the Department of Health

The United States of America As Represented by the Secretary, Department

Kirk P Manfredi

Michael R Boyd

Gerhard Bringmann

John H Cardellina, Ii

James Brislin McMahon

Gordon M Cragg

Lewis K Pannell

John W Blunt

Duncan Thomas

Johnson Jato

Robert J Gulakowski

Guido Francois

Yaii F Hallock

The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.

Process of preparing michellamine compounds

Michellamine antiviral agents, compositions, and treatment methods

The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.

Antimalarial korupensamines and pharmaceutical compositions and medical

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Frederick, MD, United States of America

Kirk P Manfredi