Genelabs Technologies, Inc.

Xdx, Inc.

Expression Diagnostics, Inc.

Other

Genelabs, Incorporated

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America As Represented by the Department of Health

The United States of America

Kirk E Fry

Robert Woodward

Jay Wohlgemuth

Ngoc Ly

Cynthia A Edwards

Charles Cantor

Beth M Andrews

Albert W Tam

Gregory R Reyes

Daniel W Bradley

Patrice O Yarbough

Krzysztof Z Krawczynski

Steven Rosenberg

Jungsuh P Kim

James Prentice

Lisa M Turin

LaVonne Marie Young

John Wages

Jeffrey M Linnen

MacDonald Morris

Russell L Dedrick

Preeti G Lal

Thomas W Bruice

Bin Wu

Michael Piatak

Megan E Laurance

Theresa P Chow

Douglas B Starr

Linda B Rabin

Yan Kwok

Gavin E Williams

James Larrick

Jingtao Sun

Moon Young Lim

The invention presents a method of diagnosing or monitoring the status of systemic lupus erythematosus (SLE) in a subject or patient comprising detecting the expression of all genes of a diagnostic set in the subject or patient wherein the diagnostic set comprises two or more genes having expression correlated with the classification or status of SLE; and diagnosing or monitoring the status of SLE in the subject or patient by applying at least one statistical method to the expression of the genes of the diagnostic set.

Methods for diagnosing and monitoring the status of systemic lupus erythematosus

Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.

Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases

The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.

Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders

Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.

Methods and compositions for diagnosing and monitoring transplant rejection

Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.

Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases

Methods of diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.

Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases

The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.

DNA binding compound-mediated molecular switch system

Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.

Enterically transmitted non-A/non-B hepatitis viral agent and characteristic epitopes thereof

Growing community of inventors

Palo Alto, CA, United States of America

Kirk E Fry