Vanderbilt University

Other

Kirk B Lane

Jeffrey M Davidson

James Loyd

William C Nichols

John A Phillips, Iii

Jennifer R Thomson

Michael W Pauciulo

Rajiv D Machado

Richard Light

Richard C Trembath

Tatiana Foroud

This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.

Method of diagnosing pulmonary hypertension

A composition comprising a nuclear localization sequence and a peptide nucleic acid oligomer (NLS-PNA) is described. Uses of the composition include, but are not limited to: regulation of gene expression, gene therapy, and the production of pharmaceutical nucleic acids and proteins. In addition, the NLS-PNA is useful for scientific and therapeutic transfection and expression of nucleic acids in cells types that previously were resistant to transfection and therapy including quiescent cells, differentiated cells, embryonic stem cells, and eukaryotic cells with intact nuclear membranes. The NLS-PNA can be combined with a membrane transport sequence (MTS) forming a novel compound referred to as an MTS-NLS-PNA wherein the MTS provides transport through the cytoplasmic membrane of a cell. A nuclear targeted peptide nucleic acid oligomer is useful for the treatment of genetic based diseases and diseases that can be treated genetically including heart disease, cancer, cerebrovascular diseases, chronic pulmonary diseases, human immunodeficiency virus, and other diseases, conditions and disorders.

Nuclear targeted peptide nucleic acid oligomer

The present invention provides a method of producing a pleurodesis in a mammal, comprising introducing a therapeutically effective dose of a pharmaceutical composition comprising TGF.beta. into the pleural cavity.

Method of producing pleurodesis

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Brentwood, TN, United States of America

Kirk B Lane