Kimmerling Holdings Group, LLC

Kirk A Kimmerling

Shi-Qiang Gong

Franklin R Tay

John Donald Blizzard

Joseph P Rapp

One-pot synthetic methods are disclosed for synthesizing curable, antimicrobial silsesquioxane-silica hybrids by hydrolytically co-condensing a tetraalkoxysilane with two different trialkoxysilanes. Particles are also disclosed that are substantially spherical and have an ordered lamellar internal structure. In addition, polymers prepared front the curable, antimicrobial silsesquioxane-silica hybrids and co-monomers are disclosed.

Synthesis of antimicrobial silsesquioxane-silica hybrids

One-pot synthetic methods are disclosed for synthesizing curable, antimicrobial silsesquioxane-silica hybrids by hydrolytically co-condensing a tetraalkoxysilane with two different trialkoxysilanes. Particles are also disclosed that are substantially spherical and have an ordered lamellar internal structure. In addition, polymers prepared from the curable, antimicrobial silsesquioxane-silica hybrids and co-monomers are disclosed.

Methods of reducing dermal penetration of at least one active ingredient in a topically applied product using compositions comprising siloxane polymers are disclosed. In some aspects, the active ingredient is an antimicrobial agent, especially benzalkonium chloride, 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, and combinations thereof.

Method of decreasing dermal absorption using composition comprising siloxane polymer

Compositions are disclosed that comprise at least one compound of formula IV: wherein the variable are as defined in the specification. The compositions are antimicrobial and optionally curable, and useful, inter alia, in dental, medical, and industrial applications for reinforcement and/or adhering two surfaces together.

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Kennesaw, GA, United States of America

Kirk A Kimmerling