Shionogi Company Limited

Shin-Etsu Chemical Co., Ltd.

Kinzaburo Noda

Toyohiko Takeda

Teruo Sakamoto

Sadao Kawai

Yusuke Suzuki

Noboru Hoshi

Toshiro Fujii

Hideyuki Maekawa

Toshihiro Ogura

Hiroshi Kato

Sustained-release formulations which can release a water-soluble active ingredient or ingredients at the zero-order over a long period of time, comprising:

Sustained-release formulation and production thereof

Highly effective and orally administrable sustained-release preparation of an antihypertensive agent, pinacidil (N'-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) comprising a rapid-release and a slow-release component at a ratio of about 7:3 to about 1:9 by pinacidil weight.

Sustained-release preparation of pinacidil

Highly potent long-acting formulation of cefaclor for treating bacterial infections in human or animals, comprising a rapid-release and a slow-release component at a ratio of about 3:7 to about 5:5 by potency of cefaclor, convenient for administration or carrying about.

Long-acting formulation of cefaclor

The sugar-coated solid dosage forms have improved disintegrability even in a neutral medium after prolonged storage, with sugar-coating layers having excellent mechanical strengths. The coating layer that is in direct contact with the surface of the solid dosage form contains a water-insoluble hydroxypropyl cellulose with a relatively low content of hydroxypropoxy groups, say, from 4 to 16% by weight. The hydroxypropyl cellulose is used by being suspended in the coating syrup or mixed in the dusting powder for purposes of subcoating. It is also possible to use the hydroxypropyl cellulose in the form of suspension to form a smoothing coat.

Sugar-coated solid dosage forms

Growing community of inventors

Hyogo, Japan

Kinzaburo Noda