Hitachi, Ltd.

Hitachi-high-technologies Corporation

Kannon Energy Co., Ltd.

Kinya Kobayashi

Kiyomi Yoshinari

Toshiyuki Yokosuka

Atsumu Hirabayashi

Yasushi Terui

Atsushi Otake

Akihiro Sano

Lee Chahn

Atsushi Ohtake

Kenko Uchida

Junnosuke Nakatsugawa

Atsushi Ootake

Hironori Matsumoto

Yuichiro Hashimoto

Haruo Akahoshi

Yuji Enomoto

Izumi Waki

Kisaburo Deguchi

Takeyuki Itabashi

Shinichi Fukada

Naoki Sakurai

Masashi Kitamura

Junpei Kusukawa

Hiroshi Morita

Kazutami Tago

Toyoharu Okumoto

Norihisa Iwasaki

Chahn Lee

Hiromichi Yamashita

Masako Ishimaru

Toshio Haba

Akihiro Takeda

Tomoyuki Kurosawa

In a calculation method of calculating a switching wave form of an inverter by expressing a wave form obtained by measurement or simulation using a function formula, an intermediate terminal is provided between an upper terminal and a lower terminal of an inverter arm and a power supply of a voltage function formula is provided between the upper terminal and the intermediate terminal or the intermediate terminal and the lower terminal. Further, it may be configured such that a variation impact from peripheral circuits at time of switching is calculated and voltage correction calculation is performed to prevent the calculated switching wave form from changing due to the calculation of the variation impact.

Calculation method of switching waveform of the inverter and circuit simulation model

Provided is an electron beam scanning method for forming an electric field for appropriately guiding electrons emitted from a pattern to the outside of the pattern, and also provided is a scanning electron microscope. When an electron beam for forming charge is irradiated to a sample, a first electron beam is irradiated to a first position () and a second position () having the center () of a pattern formed on the sample as a symmetrical point, and is then additionally irradiated to two central positions () between the first and second irradiation position, the two central positions () being on the same radius centered on the symmetrical point as are the first and second positions. Further, after that, the irradiation of the first electron beam to the central positions between existing scanning positions on the radius is repeated.

Electron beam irradiation method and scanning electronic microscope

A magnetic gear mechanism including a simplified assembly of a magnetic flux modulating section in the magnetic gear mechanism which improves the strength thereof. In the magnetic flux modulating section of the magnetic gear mechanism, the magnetic flux modulating section being formed of a magnetic member and a non-magnetic member, a piece of the magnetic member and a piece of the non-magnetic member are separately produced. The piece of the magnetic member is sandwiched between circumferential projections provided in pieces of the non-magnetic member, and the magnetic member and the non-magnetic member and bearing holding sections form a structure in which the magnetic member and the non-magnetic member are fitted into the bearing holding sections by using recessed portions provided in the bearing holding sections and axial projections provided in the pieces of the non-magnetic member. This structure simplifies production and improves strength.

Magnetic gear mechanism including a plurality of rotors or stators

A totally enclosed motor which includes a rotor disposed inside a housing and a heat of the rotor is transferred to the housing, a stator disposed inside the housing and a heat of the stator is transferred to the housing, and an inner fin which is disposed in the rotor and agitates air inside the housing. The totally enclosed motor is cooled by a forced convection by an outer fan disposed outside the housing, or by a natural convention in the vicinity of an outer surface of the housing, and a shape of the rotor is different between one end side and the other end side of the rotor in an extending direction of a rotary shaft of the rotor.

Totally enclosed motor

A solar thermal power generation apparatus including: a turbine rotatable around a vertical axis, a power generator driven by turbine; a funnel disposed along vertical axis so as to house turbine and having an intake port at the lower end of funnel; and a transparent box body disposed so as to surround a lower portion of the funnel and having the air intake port at a position being lower than the intake port and a heat collector disposed in a standing manner at a distance between the box body and the funnel. An upper end of the heat collector is at a position being higher than the intake port. By using an updraft occurred by heating air having flown from the air intake port into the inside of the box body by the heat collector, the turbine is rotated, which causes the power generator to generate power.

Solar thermal power generation apparatus

During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSspectrum is effectively utilized in each step of the MSinvolving a multi-stage dissociation and mass spectroscopy (MS), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSanalysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.

Mass spectrometer system

The present invention can provide a mass spectrometric system judging whether a measurement target is a substance required by an operator within an actual measurement time, when a substance (particularly such as protein or sugar chains) is analyzed. In the mass spectrometric system using a tandem mass spectrometer, a particular substance obtained by separating a sample is ionized, and mass analysis of the ionized substance is performed to obtain a spectrum. This spectrum is compared with a particular spectrum stored in advance, to thereby determine whether both the spectra match with each other. When a match is determined, a particular ion is further ionized within a particular time for detailed analysis. The invention also provides a mass spectrometric method, a diagnosis system and an inspection system each using the mass spectrometric system, and a program for operating a computer to control those systems with desired functions.

Mass spectrometric method, mass spectrometric system, diagnosis system, inspection system, and mass spectrometric program

The present invention provides a tandem type mass analysis system capable of carrying out the differential analysis with high efficiency by the tandem type mass analysis. A predetermined number of m/z regions are set up for carrying out the mass analysis with the all ions included therein being dissociated collectively for each m/z region so as to obtain measurement MSdata. By comparing the measurement MSdata with reference MSdata stored in a reference data base, a difference thereof is detected. For the m/z region with a differential component detected, the mass analysis is carried out collectively without dissociation for the all ions included therein so as to obtain measurement MSdata. By comparing the measurement MSdata with the reference MSdata, a difference thereof is detected. From the difference thereof, a parent ion considered to be the differential component factor is presumed for carrying out the mass analysis with the same being dissociated.

Tandem type mass analysis system and method

An object of the present invention is to provide a mass spectrometry system capable of improving an efficiency of obtaining information on a structure of substances, shortening a time taken for a measurement and substance identification, and improving identification accuracy. The system comprises: a process of mass analyzing an ionized analyte; a first fragmentation process where a first ion is selected from the ions observed in a mass spectrometry to fragment it; a process of mass analyzing a plurality of the ions generated in the first fragmentation process; a process of determining fragment ion combination capable of reconstructing the first ion using a result of the mass spectrometry; a second fragmentation process where the fragment ions contained in the fragment ion combination are fragmented; and a process of mass analyzing the fragment ions generated in the second fragmentation.

Method of identifying substances using mass spectrometry

The present invention achieves a mass analysis method that can identify protein or peptide with high speed and high sensitivity. A mass spectrum is obtained from a standard sample of healthy person, an ion is selected from the mass spectrum as a precursor ion, and a mass spectrum of the precursor ion is obtained [(a) to (d)]. A mass spectrum is obtained from a sample of interest to be measured of patient, an ion other than the precursor ion of the standard sample is selected from the mass spectrum as a precursor ion, and a mass spectrum of the precursor ion is obtained [(g) to (k)]. Identifications on peptide/protein specific to the standard sample and the sample to be measured, and common to both are conducted [(r) to (q)], and based on the results, comparative analysis on peptide/protein of the sample to be measured (t). Without regarding an ion derived from all components of the sample to be measured as precursor ion, MS/MS spectrum is obtained and identification on a plurality of components of the sample to be measured can be conducted for a short time and with high sensitivity.

Mass analysis method and mass analysis apparatus

A tandem analysis system is provided for ionizing a substance, performing mass spectrometric analysis of various ion types generated, selecting and dissociating an ion type, the ion type having a specific mass-to-charge ratio, and thereby, repeating mass spectrometric analysis measurement on the ion of the ion type over n-th stages. A processing judges control content for the analysis next to MS(the n-th stage mass spectrometric analysis) within a predetermined time, based on ion intensity being represented by an ion peak with respect to the mass-to-charge ratio of each ion in the MSresult. An ion detection unit judges isotope-peak from the measured ionized data. Assuming that the MScount number of a parent-ion peptide measured during a certain constant time-interval is I, a data processing unit makes the MSintegration number-of-times or analysis time of the peptide proportional to 1/I.

Mass spectrometric analysis method and system using the method

In a method for mass spectrometry, a plurality of juxtaposed chromatography apparatus connected to a mass spectrometer start eluting at a predetermined time difference and the following mass spectrometer conducts mass spectrometry. A chromatogram in a preceding chromatography apparatus is analyzed on real time base and results of the analysis are used on real time base to change an elusion condition of a succeeding chromatography apparatus. A mass spectrometric system suitable for carrying out the method is also provided.

Mass spectrometric method and mass spectrometric system

In a method of measuring by a tandem mass spectrometer a sample labeled with an isotope, measuring throughput is improved. In a technique in which tandem mass spectrometer is used to analyze a sample labeled with an isotope, spectra obtained by a first-stage measurement (MS) are analyzed during a measuring session in a realtime fashion to determine ions to be used in second-stage and subsequent dissociation&#x2022; spectral measurement (MS2).

Mass spectrometry and mass spectrometry system

A main object is to cope with an unknown structure substance thereby to identify the structure of a parent ion highly precisely and to derive a supposed structure. A method for analyzing mass spectrometric data is disclosed, which: acquires mass spectrometric data on an ionized sample and dissociated ions dissociated from the sample as a parent ion; derives dissociated ion candidates by analyzing the molecular orbits on the candidates of the structures of the parent ion; and displays the analytical results of the parent ion candidates and the dissociated ion candidates and compares the data of the dissociated ion candidates and the data of dissociated ions actually measured, to evaluate the structures of the parent ion candidates.

Mass spectrometric data analyzing method, mass spectrometric data analyzing apparatus, mass spectrometric data analyzing program, and solution offering system

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Hitachi, Japan

Kinya Kobayashi