Mitsubishi Pharma Corporation

Traditional Chinese Medicine Research Laboratory, Inc.

Lequio Pharma Co., Ltd.

Kinuko Oku

Takashi Ono

Hideo Okazaki

Takako Iwamoto

Optimum compounding composition of a local injection preparation for treating rectal submucous lesioned abnormal tissue with local anesthetic is decided to provide a medical composition kit. In a composition kit for the treatment where respective containers are unsealed upon being used and respective contents are mixed to obtain a preparation for injection, a medical composition kit which is characterized in that respective single doses of a therapeutic preparation and local anesthetic are fractionally charged in containers, the said therapeutic preparation contains 1&#x2dc;10% of a water-soluble aluminum compound and 0.01&#x2dc;2% of tannic acid and the said local anesthetic contains 0.1&#x2dc;1% of lidocaine hydrochloride or 0.5&#x2dc;5% of procaine hydrochloride.

Medical composition kit for treating lesioned abnormal tissue

Injectable compositions for treating affected tissues are prepared by formulating sodium hydrogen sulfite with all other components except tannic acid to yield a first mixture and adding tannic acid to the first mixture, or, by formulating a water-soluble aluminum compound and a chelating agent to yield a first formulation, formulating tannic acid and sodium hydrogen sulfite to yield a second formulation and admixing the first formulation with the second formulation to yield a second mixture and, as needed, adding a polyvalent alcohol and/or a saccharide to the first and/or second formulations or to the first or second mixture, thereby formulating the injectable composition having a pH range of from pH 1.0 to pH 3.5. This preparation can prevent the oxidation of tannic acid and the direct reaction with aluminum ions derived from sodium hydrogen sulfite, whereby the composition can provide a stable formulation as well as ensure effectiveness as an injectable preparation in a solution form.

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Naha, Japan

Kinuko Oku