Otsuka Pharmaceutical Factory, Inc.

Otsuka Pharmaceutical Company, Limited

Kinji Hashimoto

Takashi Okamura

Makoto Inoue

Kiyoto Goto

Kenichi Kanai

Tetsuya Sato

Hiroshi Ishikawa

Hidetsugu Tsubouchi

Yasuhide Inoue

Kazuyoshi Miyata

Yasuo Shoji

Koushi Iwata

Hitoshi Ohno

Tsuneo Yasuda

Akifumi Hagi

Kinue Ohguro

Motoya Kikuchi

Masayuki Ohara

Masatoshi Inai

Yoshiaki Tsuda

Keisuke Miyajima

Junichi Minamikawa

Takeshi Yamauchi

Hiroshi Kiyokawa

Kunihiko Tatsumi

Takuji Uesako

Toshiko Kuwahara

Ken-ichi Kanai

Yoshifumi Chone

Kazunobu Kurisu

Yukio Sugimoto

Toshiaki Funato

The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.

Aqueous solution of olanexidine, method of preparing the aqueous solution, and disinfectant

Pyrazolo[1,5-a]pyrimidine derivatives

Analgesic composition of pyrazolo(1,5-A) pyrimidines

Pyrazolo�1,5-a!pyrimidine derivative

Pyrazolo�1,5-A!pyrimidine derivatives and anti-inflammatory agent

Pyrimidine derivatives, method of manufacturing the same, and androgen

A p-aminophenol derivative having anti-inflammatory activity, represented by the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a C.sub.1-6 acyl group; Ar is a pyrazine, pyrazine N-oxide, thiazole, benzene, pyridine, pyridazine, pyrimidine or triazine ring; R.sup.3 is a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy-carbonyl-C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a halogen atom or a carboxy-C.sub.1-6 alkyl group; A is a C.sub.1-6 alkylene group; and B is a C.sub.1-6 alkyl group, or a salt thereof.

P-aminophenol derivatives, and processes for production of and uses for

The invention relates to a salt selected from group consisting of alkali metal salts and alkaline earth metal salts of an optically active form of a 4-hydroxy-8-(3-lower alkoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine, a process for producing said optically active compound or salt thereof, and a pharmaceutical composition, such as an antipodagric agent, comprising an effective amount of the salt together with a pharmaceutically acceptable nontoxic carrier.

Salts of optically active 4-hydroxy-8(3-lower

This invention provides thiazole derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined above, and salts thereof. These compounds have particularly potent angiogenesis inhibiting activity.

Thiazole derivatives

3-halogeno-2,3-diphenylacrylaldehyde derivatives, process for preparing

Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group;

N-heterocyclo-substituted p-aminophenols

Disclosed are phenol derivatives of the formula ##STR1## wherein R.sup.1 is a substituted phenyl group, R.sup.2 and R.sup.3 are C.sub.1 -C.sub.6 alkyl group and of the formula ##STR2## wherein R.sup.8, R.sup.9 and R.sup.10 are C.sub.1 -C.sub.6 alkyl and the like and A is H, C.sub.1 -C.sub.6 alkylsulfonyl and the like substituents. These compounds and some related compounds have anti-inflammatory activity and lipoxygenase inhibitory activity.

Phenol derivatives, their preparation and the use thereof

N-pyrazinyl substituted P-aminophenols

Growing community of inventors

Naruto, Japan

Kinji Hashimoto