Purdue Research Foundation

Innovational Holdings LLC

Akina, Inc.

Conor Medsystems, Inc.

Sk Joint Ventures Ii, LLC

United States Surgical Corporation

The United States Government As Represented by the Department of Veterans Affairs

Indiana University

Chong Kun Dang Pharmaceutical Corporation

Symic Biomedical, Inc.

Samyang Corporation

Samyang Biopharmaceuticals Corporation

Kinam Park

Haesun Park

John Francis Shanley, Iv

Alyssa Panitch

Yeonhee Yun

Sarah Michelle Skidmore

Byung Kook Lee

Stephen Hunter Diaz

Neal L Eigler

Elazer Reuven Edelman

John Eric Paderi

Katherine Allison Stuart

Steve Higbee

John Solomon Garner

Yoon Yeo

John J Garner

Osman Basaran

Jun Chen

Ghanashyam S Acharya

Terry L Bowersock

Yourong Fu

Thomas J Webster

Theodore L Parker

David H Thompson

Gil U Lee

Chaul Min Pai

Sang Yeob Park

Brian C Ward

Bumsoo Han

Hossein Omidian

Bong Kwan Soh

Christine A Hrycyna

Dukjoon Kim

Rebecca Scott

Gun Seomoon

Ghanashyam Acharya

Robert E Porter, Jr

William E Blevins

Waleed S Shalaby

Michel Levy

Clark Tobias Barco

Kalpana R Kamath

Timothy McPherson

Seongbong Jo

Seong BongJo

Gwangheum Yoon

Larry Fultz

Andrew David Otte

Michael Sturek

James Wodicka

Alvin Un-Teh Chen

Shicheng Yang

Yong Qiu

Igal Szleifer

Bongseop Kwak

Grace E Park

Crystal Soo Jung Shin

Elazar R Edelman

Katherine Stuart

Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such astoxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such astoxin, are also provided. Precipitatedtoxin andtoxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

Biodegradable polymer formulations for extended efficacy of botulinum toxin

A solid crosslinked polyester composition is disclosed wherein the crosslinked polyester is environmentally degradable in less than about 180 days. The crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, and one or more multi-carboxylic acid compounds. Alternately, the crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, one or more multi-carboxylic acid compounds, and a cyclic ester.

Synthesis of environmentally degradable alkyl polyesters

Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

The present disclosure relates to naltrexone sustained release microparticle delivery systems for the treatment of diseases ameliorated by naltrexone. The injectable microparticle delivery system includes naltrexone encapsulated in biodegradable microparticles administered in a pharmaceutically acceptable vehicle.

Injectable long-acting naltrexone microparticle compositions

The invention relates to peptide conjugates that can bind to endothelial cells, and that are useful for reducing the incidence and severity of endothelial dysfunction in mammals.

Selectin and ICAM/VCAM peptide ligand conjugates

This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

Collagen-binding synthetic peptidoglycans, preparation, and methods of use

Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.

Sol-gel phase-reversible hydrogel templates and uses thereof

The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.

Hydrogel tissue expanders

A semi-automated device that provides a mechanism to produce large-scale microparticle formulations of specific sizes with no scum layer formation, and a method for using the device.

Device for large-scale microparticle production and method of using the same

Drug eluting stents (DES) useful for the treatment of restenosis are described. The stents comprise biocompatible polymers and adenosine receptor modulators.

Drug-eluting stents for adenosine receptor modulation

The present invention relates to method for loading a beneficial agent into an expandable medical device. The method includes the steps of sealing a plurality of openings extending through the medical device from a first side to a second side with a sealing member to substantially prevent a beneficial agent from passing through the openings, partially filling the openings with the beneficial agent delivered from an automated micro-jetting dispenser, substantially solidifying the beneficial agent, and removing the sealing member from the plurality of openings.

Method and apparatus for loading a beneficial agent into an expandable medical device

A system is provided that simulates the in vivo micro-environment of three-dimensional cellular structures or bodies, such as tumors. The system simulates the pressure gradients and fluid flows of the vascular and lymphatic systems as well as the interstitial and capillary transport mechanisms between the 3D cellular structure and the vascular and lymphatic systems. The system can be used to introduce drugs or drug delivery carriers to a tumor, for example, to assess the uptake capability and effect on the tumor. The system maintains the viability of the tumor cells for a sufficiently long period of time to permit testing of several different drugs and/or delivery carriers.

Systems and methods for testing drugs and drug delivery systems

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Kinam Park