Takeda Chemical Industries, Inc.

Kin-ichi Imai

Toshimi Matsuno

Mitsuhiko Mano

Improved processes for producing purine derivatives, such as 9-(2-chloro-6-fluorobenzyl)-6-methylaminopurine, which are useful as anticoccidial agents, and new arylazopyrimidine compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen, C.sub.1-3 alkyl, allyl or dihalobenzyl, and when either one of R.sup.1 and R.sup.2 is hydrogen, the other is other than hydrogen, and R.sup.3 is aryl, and acid addition salts thereof, which are useful as intermediates for production of the purine derivatives.

Production of purine derivatives and intermediates therefor

Novel purine derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sup.2 is alkyl of 1 to 3 carbon atoms or allyl, and R.sup.3 and R.sup.4, respectively, mean halogen, and their acid addition salts are provided. These compounds have anticoccidial activity and are useful for treating caecal and/or intestinal coccidiosis in poultry and domestic animals.

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Toyonaka, Japan

Kin-ichi Imai