Reliant Technologies, Inc.

Avinger, Inc.

Biopharmx, Inc.

Kin F Chan

Leonard C DeBenedictis

Himanshu N Patel

David A Dewey

George Frangineas, Jr

Manish Kankaria

John B Simpson

Michael H Rosenthal

Maegan K Spencer

Michael Zung

Charles W McNall

John F Black

Nicholas J Spinelli

Dennis W Jackson

Christopher B White

Evangeline Lumabas

Benjamin Ngo

Basil M Hantash

George Frangineas

Thomas R Myers

G Scott Herron

Robert Kehl Sink

Vikramaditya P Bedi

Leonard C Debenedictis

Charles W Mcnall

A system for imaging a body lumen includes a controller and a display. The controller is configured to connect to a proximal end of a catheter having an optical fiber extending along the length of an elongate catheter body. The controller is further configured to rotate a distal end of the optical fiber from a location near a proximal end of the elongate catheter body, acquire optical coherence tomography (OCT) images using the optical fiber as the distal end of the optical fiber rotates, and determine a rotational lag of the distal end of the optical fiber. The display is configured to display one or more OCT images corrected for the rotational lag.

Catheter-based off-axis optical coherence tomography imaging system

A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly.

Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters

Provided herein is a topical composition and related methods for making and using the composition. In a first aspect, the topical composition comprises a magnesium salt (e.g. magnesium chloride) dissolved in an anhydrous or non-aqueous solvent. Exemplary solvents comprise a monohydric aliphatic alcohol, and a polyol.

Magnesium chloride composition for dermatological use

Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.

Subjects treated with nonablative fractional photothermolysis (FP) have an intact stratum corneum, but can have microscopic lesions and vacuole formation within the epidermis. The vacuoles thus formed can trap dermal material and extrude it through the epidermis. Thus, FP can be used for the treatment of recalcitrant melasma, solar elastosis, and tattoos.

Laser-induced transepidermal elimination of content by fractional photothermolysis

The present invention relates to a method and apparatus for using an imaging detector to image an optical pattern created by illumination of a viscous material that is applied to the skin. The viscous material forms a detectable pattern that can be imaged by the imaging detector. In some examples, the viscous material is reflective and allows reflection from an illumination source to create an optical pattern on the imaging detector. In other cases, the variation in thickness of an absorbing or scattering viscous substance can be imaged by the detector. Polarized illumination and detection can be used to enhance the response.

Method and apparatus for monitoring and controlling laser-induced tissue treatment

Methods and devices for treatment of skin are disclosed. These methods and devices use electromagnetic radiation to create networks or patterns of treatment zones. The networks or patterns of treatment zones comprise at least four treatment zones, at least two of the treatment zones in the network or pattern are slanted at angles in the skin, and the treatment zones extend at least as deep as the dermal-epidermal junction of the skin. Producing intersecting treatment zones and/or overlapping treatment patterns can increase the effectiveness of the treatments. The devices comprise a hand piece operably coupled to a delivery element, wherein delivery of electromagnetic radiation through the device to a portion of skin produces a network or pattern of treatment zones. The use of these methods and devices results in tightening of the skin and/or improvement in the cosmetic appearance of wrinkles in the portion of skin treated.

Method and device for tightening tissue using electromagnetic radiation

In a fractional treatment system, an adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements. In one aspect, the fractional treatment is configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue decreases as the tissue is heated by the laser (e.g., 1480-1640 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 7 cmto about 26 cm.

Apparatus and method for adjustable fractional optical dermatological treatment

A fractional treatment system can be configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue increases as the tissue is heated by the laser (e.g., 1390-1425 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 8 cmto about 30 cm. An adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. The system may be designed to be switchable between a treatment mode that is semi-ablative and a treatment mode that is not semi-ablative. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements.

Growing community of inventors

San Jose, CA, United States of America

Kin F Chan