Zenyaku Kogyo Kabushiki Kaisha

Kimitomo Yoshioka

Hiroaki Yamazaki

Muneaki Takase

Tetsuo Watanabe

Toshiyuki Matsuno

Shinichi Yaguchi

Yoshio Tsuchida

Susumu Mitsuhashi

Kazuhiko Haruta

Hideshi Kobayashi

Ryogo Yui

Ichiro Washizawa

Sosuke Yasui

A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient

Heterocyclic compounds of the formula: ##STR1## and a cardiotonic agent containing the same which have an excellent positive inotropic effect and which suppress increase of heart rate.

Heterocyclic compound and cardiotonic agent containing the same as

A thiazole derivative represented by the formula I, pharmaceutically acceptable acid addition salt thereof, and a process for preparation thereof ##STR1## wherein R.sub.1 represents --COOR.sub.4, ##STR2## or cyano wherein R.sub.4 represents hydrogen or lower alkyl, and

Thiazole derivatives and medical compositions thereof

1,4-thiazine derivative, and cardiotonic agent comprising it as

Disclosed is a novel 1,4-thiazine derivatives represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 respectively represent a hydrogen atom or a lower alkyl group. Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II: ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above, A represents a group ##STR3## in which X represents a halogen atom and n is a number of 1 to 3, and X' represents a halogen atom which may be the same as or different from X, and reacting the compound of the general formula II with sulfur at elevated temperature or stirring the compound of the general formula II in a solution system comprising zinc and a carboxylic acid. Further disclosed is a cardiotonic agent comprising a pharmaceutically acceptable excipient and, as the active component thereof, an effective amount of the novel 1,4-thiazine derivative having the general formula I.

1,4-Thiazine derivatives

Polysaccharide PS-A obtained from barrenwort deriving from plants

The present invention provides an extract obtained by extracting a plant belonging to the genus Epimedium sp. with a mixed solvent of water and a water-miscible organic solvent or with water, defatting the obtained aqueous extract and collecting a high-molecular compounds-containing fraction from the defatted aqueous extract, a process for preparation of this extract, an antibacterial agent comprising this extract as an effective component and an antibacterial therapy by using this extract.

Extract from barrenwort

Growing community of inventors

Tokyo, Japan

Kimitomo Yoshioka