Showa Denko K.k.

Showa Denko Kabushiki Kaisha

Kimitaka Ohshiro

Hiroshi Yasuda

Makoto Saito

Hideo Miyata

Kuniomi Marumo

Kohei Morikawa

Akira Shibuya

Haruaki Ito

Sumio Soya

Yutaka Ohnishi

Kaneo Nozawa

Yoshiaki Miyota

Takashi Tani

Masaru Yasuda

There is provided a process for producing an aminomethyl group-containing benzamide compound represented by the general formula (II): wherein &#x2014;CONH2 and &#x2014;X represent a substituent on the benzene ring and &#x2014;CONH2 exists at the meta- or para-position of &#x2014;CH2NH2, and X and n are as defined below, which comprises hydrating an aminomethyl group-containing benzonitrile compound represented by the general formula (I): wherein &#x2014;CN and &#x2014;X represent a substituent on the benzene ring and &#x2014;CN exists at the meta- or para-position of &#x2014;CH2NH2, X represents a chlorine atom or a fluorine atom, and n represents an integer of 0 to 4, provided that, when n is 2 or more, X may be the same or different 

Production process of aminomethyl group-containing benzamide compound

A process for producing a cyanobenzoic acid compound, a cyanobenzamide compound, an alkyl cyanobenzoate compound, and a cyanobenzoyl chloride compound, which are useful intermediates for a variety of chemicals such as pharmaceuticals, agrochemicals, liquid crystals, and monomers for functional polymers. One nitrile group of an easily available phthalonitrile compound is selectively hydrolyzed to thereby produce a cyanobenzamide compound with high selectivity and yield. The cyanobenzamide compound thus-produced is transformed under acidic conditions into a cyanobenzoic acid compound and a cyanobenzoate ester compound without the cyano group of the benzene ring being damaged.

Process for producing cyanobenzoic acid derivatives

(1) Methods for producing isochromanone compounds from o-xylene compounds as starting compounds through &agr;-halogeno-o-xylene derivatives, &agr;-cyano-o-xylene derivatives, and &agr;-halogeno-&agr;&prime;-cyano-o-xylene derivatives, and (2) methods for producing isochromanone compounds from o-xylene compounds as starting compounds through &agr;,&agr;&prime;-dihalogeno-o-xylene derivatives, &agr;,&agr;&prime;-dihydroxy-o-xylene derivatives, &agr;-halogeno-&agr;&prime;-hydroxy-o-xylene derivatives and &agr;-cyano-&agr;&prime;-hydroxy-o-xylene derivatives, and methods for producing these intermediate compounds.

Process for producing isochromanones and intermediates thereof

Method for producing cyanophenyl derivatives

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Kanagawa, Japan

Kimitaka Ohshiro