Otsuka Pharmaceutical Company, Limited

Torii & Co., Ltd.

Kimio Sudo

Setsuro Fujii

Hiroshi Ishikawa

Hidetsugu Tsubouchi

Koichi Yasumura

Koichiro Jitsukawa

Sachio Toyama

Toyoo Nakayama

Toshiyuki Okutome

Shigeki Nunomura

Masateru Kurumi

Takuo Aoyama

Kouichi Tsuji

Yojiro Sakurai

Shinichi Watanabe

Koichi Tsuji

Shin-ichi Watanabe

Setsurou Fujii

Tetsuhiko Shirasaka

Ryoji Matsui

There is provided a cephalosporin derivative represented by the general formula (1): ##STR1## wherein R.sup.101, R.sup.102, R.sup.103 and Y.sup.101 are as difined; the general formula (2): ##STR2## wherein R.sup.201, R.sup.202 and R.sup.203 are as defined above; the general formula (3): ##STR3## wherein R.sup.301, R.sup.302, Y.sup.301, Y.sup.302 and A.sup.301 are as defined; or pharmaceutically acceptable salt thereof. The compound is useful as an active ingredient of antimicrobial agent.

Isocephem derivatives, and antimicrobial composition containing the

A 2-oxa-isocephem compound of the formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined, pharmaceutically acceptable salts thereof, composition containing the same and processes for preparing the same are disclosed. The compound is useful as an antimicrobial agent.

2-oxa-isocephem compounds

There is described a 2-oxa-isocephem compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined, and R.sup.3 is a group of the formula: ##STR2## wherein n, m, R.sup.6, R.sup.7, B.sup.- and l are as defined, or pharmaceutically acceptable salt thereof. The compound has antimicrobial activity.

2-oxa-isocephem compounds, compositions containing the same and

2-Oxa-isocephem compounds and compositions containing same

A 2-oxa-isocephem compound of the formula (1): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined, pharmaceutically acceptable salts thereof, esters of the carboxy group in the 4-position thereof and quaternary ammonium salts thereof, composition containing the same and processes for preparing the same are disclosed. The compound is useful as an antimicrobial compound.

2-oxa-isocephem compounds, compositions containing same and processes of

Amidine compounds of formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) ##STR2## or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) ##STR3## or preferably an acid addition salt thereof.

6-amino-2-naphthyl 4-gusnichinobenzoate derivatives and pharmaceutical

6-Amidino-2-naphthyl 4-guanidinobenzoate derivatives and pharmaceutical

Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.

Novel amidine compound

Amidine compounds

Growing community of inventors

Otsu, Japan

Kimio Sudo